Belt Haley, Kypreos Margaret, Lu An, Hernandez-Velasquez Ginna, Mehta Roma
Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, USA.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA.
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251356334. doi: 10.1177/23247096251356334. Epub 2025 Jul 17.
The global incidence of invasive mucormycosis (mucor) infection is on the rise due in part to an increased utilization of immunosuppressive therapies to treat malignancies and autoimmune diseases. While cirrhosis has previously been considered a risk factor for fungal infections, very little is known about the inciting factors precipitating development of isolated cutaneous mucormycosis infection. This form of mucor poses a significant mortality risk despite antifungal and surgical treatments and has been documented in only 5 patients with cirrhosis prior to our case report. This case report presents the sixth documented case of cutaneous mucormycosis in a patient with cirrhosis and explore nosocomial etiologies for its progression to clinically significant infection.
侵袭性毛霉菌病（毛霉）感染的全球发病率正在上升，部分原因是用于治疗恶性肿瘤和自身免疫性疾病的免疫抑制疗法的使用增加。虽然肝硬化以前被认为是真菌感染的一个危险因素，但对于引发孤立性皮肤毛霉菌病感染的诱发因素知之甚少。尽管进行了抗真菌和手术治疗，但这种形式的毛霉仍具有很高的死亡风险，在我们的病例报告之前，仅有5例肝硬化患者有相关记录。本病例报告介绍了肝硬化患者皮肤毛霉菌病的第六例记录病例，并探讨了其发展为具有临床意义感染的医院感染病因。
