Song Lei, Wei Ziang, Shang Pan, Hu Shijie, Chen Lei, Niu Lili, Wang Yan, Gan Mailin, Shen Linyuan, Zhu Li, Zhao Ye
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province (FAGREIKLSP), Sichuan Agricultural University, Chengdu, Sichuan, PR China.
State Key Laboratory of Swine and Poultry Breeding Industry, Sichuan Agricultural University, Chengdu, Sichuan, PR China.
Virulence. 2025 Dec;16(1):2530171. doi: 10.1080/21505594.2025.2530171. Epub 2025 Jul 17.
Protein acylation modification is one of the most important protein post-translational modifications, which regulates the function of the protein by adding acyl groups to the residues of the protein. Protein acylation plays a crucial role in viral infection. Acylation can influence viral proteins, thereby regulating processes such as viral entry, replication, and assembly. Additionally, acylation regulates viral infection by regulating interferon pathway, cell metabolism, and signal transduction. This paper mainly elucidates the mechanism of acetylation, succinylation, and palmitoylation in the regulation of viral infection.
蛋白质酰化修饰是最重要的蛋白质翻译后修饰之一，它通过向蛋白质残基添加酰基来调节蛋白质的功能。蛋白质酰化在病毒感染中起着至关重要的作用。酰化可以影响病毒蛋白，从而调节病毒进入、复制和组装等过程。此外，酰化通过调节干扰素途径、细胞代谢和信号转导来调节病毒感染。本文主要阐述乙酰化、琥珀酰化和棕榈酰化在调节病毒感染中的机制。
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