Zhao Gejie, Zhou Jia, He Shutong, Fei Xiao, Guo Guijie
Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Fujian Province Joint Laboratory of Animal Pathogen Prevention and Control of the "Belt and Road", College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Int J Mol Sci. 2025 Jul 10;26(14):6613. doi: 10.3390/ijms26146613.
Lactylation, a novel form of post-translational modifications (PTMs) of protein, particularly within histone proteins, has recently gained attention for its role in regulating gene expression and cellular processes. In recent years, lactylation has been widely studied in cancer, immune diseases, neurological diseases, cardiovascular diseases, metabolic diseases, etc. Increasing evidence now suggests that lactylation also plays a significant role in the host's innate immune response to viruses. Lactylation influences fundamental cellular functions, including transcriptional regulation, signal transduction, cell proliferation and differentiation. It affects protein behavior by modulating their function, stability, subcellular localization and interactions. Studies have shown that many viral infections promote lactate production through enhanced glycolysis, a process that facilitates viral replication. Given that innate immunity serves as the host's first line of defense against pathogenic invasion, understanding how lactylation regulates antiviral responses offers promising avenues for the development of diagnostic tools and therapeutic strategies against viral diseases. In this review, we provide a comprehensive overview of recent research on the role of lactylation in viral-host interactions.
乳酰化是蛋白质翻译后修饰（PTM）的一种新形式，特别是在组蛋白中，近年来因其在调节基因表达和细胞过程中的作用而受到关注。近年来，乳酰化在癌症、免疫疾病、神经疾病、心血管疾病、代谢疾病等方面得到了广泛研究。越来越多的证据表明，乳酰化在宿主对病毒的固有免疫反应中也起着重要作用。乳酰化影响基本的细胞功能，包括转录调控、信号转导、细胞增殖和分化。它通过调节蛋白质的功能、稳定性、亚细胞定位和相互作用来影响蛋白质行为。研究表明，许多病毒感染通过增强糖酵解促进乳酸生成，这一过程有利于病毒复制。鉴于固有免疫是宿主抵御病原体入侵的第一道防线，了解乳酰化如何调节抗病毒反应为开发针对病毒性疾病的诊断工具和治疗策略提供了有前景的途径。在这篇综述中，我们全面概述了最近关于乳酰化在病毒-宿主相互作用中作用的研究。
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