Dimeglio Chloé, El Rakaawi Mohamed, Boineau Jérôme, De Smet Clémentine, Abravanel Florence, Lhomme Sébastien, Bardiaux Laurent, Izopet Jacques
Laboratory of Virology, National Reference Center on HEV, Institut Fédératif de Biologie, Toulouse University Hospital, Toulouse, France.
INSERM UMR 1291, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France.
J Med Virol. 2025 Jul;97(7):e70483. doi: 10.1002/jmv.70483.
The sources and routes of HEV infections in industrialized countries are not fully defined. Occitanie in Southern France is an hyperendemic area but the relative extent of contaminated food and water consumption is unknown. We used validated assays to determine IgG and IgM seroprevalence among 3480 French blood donors living in Occitanie and compared the data with those obtained about twelve years ago. Epidemiological information was collected using a specific questionnaire. HEV IgG seroprevalence increased from 39.1% in 2011% to 47.8% in 2023. Unlike 12 years ago, the wastewater treatment method and tap water consumption were linked to HEV infection. Consumption of bottled water is now a risk factor for HEV infection. Overall IgM seroprevalence was 1.3%. The high prevalence of anti-HEV IgG in Occitanie cannot be explained by eating habits alone. Water consumption and treatment also appear to be important factors of HEV infections in Southern France.
在工业化国家，戊型肝炎病毒（HEV）感染的来源和途径尚未完全明确。法国南部的奥克西塔尼是一个高流行地区，但受污染食物和饮用水消费的相对程度尚不清楚。我们使用经过验证的检测方法来确定居住在奥克西塔尼的3480名法国献血者中的IgG和IgM血清阳性率，并将数据与大约十二年前获得的数据进行比较。使用特定问卷收集流行病学信息。HEV IgG血清阳性率从2011年的39.1%升至2023年的47.8%。与12年前不同，废水处理方法和自来水消费与HEV感染有关。饮用瓶装水现在是HEV感染的一个危险因素。总体IgM血清阳性率为1.3%。奥克西塔尼抗HEV IgG的高流行率不能仅用饮食习惯来解释。水的消费和处理似乎也是法国南部HEV感染的重要因素。
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