Centre National de Référence (CNR) des Virus des Hépatites à Transmission Entériques (Hépatite A et E), Laboratoire de Virologie, CHU Toulouse, 31300 Toulouse, France.
Infinity, Université Toulouse, CNRS, Inserm, UPS, 31024 Toulouse, France.
Viruses. 2023 May 11;15(5):1149. doi: 10.3390/v15051149.
The identification of seven cases of hepatitis E virus infection in a French rural hamlet in April 2015 led to investigations confirming the clustering and identifying the source of the infection. Laboratories and general practitioners in the area actively searched for other cases based on RT-PCR and serological tests. The environment, including water sources, was also checked for HEV RNA. Phylogenetic analyses were performed to compare HEV sequences. No other cases were found. Six of the seven patients lived in the same hamlet, and the seventh used to visit his family who lived there. All HEV strains were very similar and belonged to the HEV3f subgenotype, confirming the clustering of these cases. All the patients drank water from the public network. A break in the water supply to the hamlet was identified at the time the infection probably occurred; HEV RNA was also detected in a private water source that was connected to the public water network. The water flowing from the taps was quite turbid during the break. The private water supply containing HEV RNA was the likely source of the contamination. Private water supplies not disconnected from the public network are still frequent in rural areas, where they may contribute to public water pollution.
2015 年 4 月，法国一个农村小村庄发现了 7 例戊型肝炎病毒感染病例，随后进行了调查，确认了感染的聚集性并确定了感染源。该地区的实验室和全科医生根据 RT-PCR 和血清学检测积极寻找其他病例。还对环境（包括水源）进行了检查，以检测 HEV RNA。进行了系统进化分析以比较 HEV 序列。未发现其他病例。7 名患者中有 6 人居住在同一个村庄，第 7 人曾去那里的家人处拜访。所有的 HEV 株非常相似，属于 HEV3f 亚型，证实了这些病例的聚集性。所有患者均饮用公共网络提供的水。在感染可能发生时，发现村庄的供水中断；在与公共供水管网相连的私人水源中也检测到了 HEV RNA。停水期间，从龙头流出的水相当浑浊。含有 HEV RNA 的私人供水可能是污染的来源。在农村地区，仍经常出现未与公共网络断开的私人供水，这可能导致公共水污染。
