Suzuki Y
Nihon Seikeigeka Gakkai Zasshi. 1985 Jul;59(7):707-18.
The changes in microcirculation dynamics were investigated, after giving acute compression to the spinal cord in rabbits. When the 8th thoracic cord was compressed for one minute with a plummet weighing 50g, paraparesis occurred, from which the animals could recovered within two weeks. The blood flow at the compressed region, determined by the hydrogen clearance method, one hour after the injury was increased to 154% of the pre-injury level, while the flow was reduced by 22% six hours later. The vascular permeability, estimated by the fluorescein method, was found to be 3.3 times greater in the injured animals than that in controls only at one hour after compression. The water contents of the spinal cord, determined by the dry weight method, were gradually increased up to six hours. These results suggest that vasogenic edema due to the primary damage to the vascular system in the spinal cord may occur within one hour of the compression and cytotoxic edema may appear six hours later.
在对家兔脊髓进行急性压迫后，对微循环动力学变化进行了研究。当用一个50克重的坠锤对第8胸髓压迫1分钟时，动物出现了双侧轻瘫，且在两周内可恢复。通过氢清除法测定，损伤后1小时，受压区域的血流量增加至损伤前水平的154%，而6小时后血流量减少了22%。通过荧光素法估算，仅在压迫后1小时，损伤动物的血管通透性比对照动物高3.3倍。通过干重法测定，脊髓的含水量在6小时内逐渐增加。这些结果表明，脊髓血管系统原发性损伤导致的血管源性水肿可能在压迫后1小时内发生，而细胞毒性水肿可能在6小时后出现。
