Faculty of Kinesiology and Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK, S4S 0A2, Canada.
Department of Kinesiology and Athletic Training, University of Northern Iowa, Cedar Falls, IA, USA.
Curr Osteoporos Rep. 2024 Nov 1;23(1):1. doi: 10.1007/s11914-024-00895-x.
Sarcopenia, generally characterized by the age-related reduction in muscle strength, lean/muscle mass and functional ability, is also associated with reduced bone mass and strength and impaired brain health and function. One potential intervention which has received much 'hype' over the past few decades to countermeasure these negative consequences of biological aging is creatine monohydrate supplementation.
From a skeletal muscle perspective, the combination of creatine monohydrate supplementation and resistance training provides 'hope' for older adults as it improves measures of lean mass, regional (limb) muscle thickness, upper- and lower-body muscle strength and functional ability. Further, there is some evidence that creatine (supplementation or habitual diet) provides a ray of 'hope' for improving some aspects of cognitive function. The majority of research suggests that creatine is more 'hype' than 'hope' for improving measures of bone mass in older adults. Creatine monohydrate supplementation provides some anti-sarcopenic benefits for older adults.
肌肉减少症通常表现为与年龄相关的肌肉力量、瘦体重/肌肉质量和功能能力下降，也与骨量和骨强度下降以及大脑健康和功能受损有关。在过去几十年中，有一种潜在的干预措施受到了很多关注，即补充肌酸一水合物，以对抗生物衰老的这些负面影响。
从骨骼肌的角度来看，肌酸一水合物补充与阻力训练相结合为老年人提供了“希望”，因为它可以改善瘦体重、区域（肢体）肌肉厚度、上下肢肌肉力量和功能能力的衡量标准。此外，有一些证据表明，肌酸（补充或习惯性饮食）为改善认知功能的某些方面提供了一线“希望”。大多数研究表明，肌酸对改善老年人的骨量指标更多的是“炒作”而非“希望”。肌酸一水合物补充为老年人提供了一些抗肌肉减少症的益处。
