Candow Darren G, Kirk Ben, Chilibeck Philip D, Duque Gustavo
Faculty of Kinesiology and Health Studies, University of Regina, Regina, Canada.
Department of Medicine, Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.
Curr Opin Clin Nutr Metab Care. 2025 May 1;28(3):235-239. doi: 10.1097/MCO.0000000000001118. Epub 2025 Feb 21.
Osteosarcopenia is an age-related condition characterized by reductions in bone mineral, muscle/lean mass, strength and functional ability which increases the risk of falls, fractures, frailty and premature mortality. One main contributing factor to osteosarcopenia is malnutrition. The purpose was to review recent evidence of creatine monohydrate (CrM) supplementation in older adults and to discuss the potential to manage osteosarcopenia.
Accumulating research shows that CrM supplementation, primarily when combined with exercise training, has the potential to serve as a viable intervention in the management of osteosarcopenia. Collectively, CrM supplementation during exercise training in older adults led to greater improvements in whole-body lean mass, lower-limb muscle density and bone geometry and muscle strength (primarily upper-body) compared to exercise training alone. However, no study has investigated the effects of CrM, with and without exercise training, in older adults with osteosarcopenia.
Given the positive findings of CrM on measures of muscle and bone in healthy older adults, there is potential for CrM to be added as an adjunct to exercise training in the management of osteosarcopenia. However, randomized clinical trials are needed to confirm the safety and efficacy of this nutrient in this clinical population.
骨质疏松性肌少症是一种与年龄相关的病症，其特征是骨矿物质、肌肉/瘦体重、力量和功能能力下降，这会增加跌倒、骨折、虚弱和过早死亡的风险。营养不良是骨质疏松性肌少症的一个主要促成因素。本文旨在综述近期关于老年人补充肌酸单水合物（CrM）的证据，并探讨管理骨质疏松性肌少症的潜力。
越来越多的研究表明，补充CrM，主要是与运动训练相结合时，有可能成为管理骨质疏松性肌少症的一种可行干预措施。总体而言，与单独进行运动训练相比，老年人在运动训练期间补充CrM能使全身瘦体重、下肢肌肉密度、骨几何形态和肌肉力量（主要是上身）得到更大改善。然而，尚无研究调查CrM在有或没有运动训练的情况下对患有骨质疏松性肌少症的老年人的影响。
鉴于CrM对健康老年人的肌肉和骨骼指标有积极作用，在管理骨质疏松性肌少症时，有可能将CrM作为运动训练的辅助手段。然而，需要进行随机临床试验来证实这种营养素在该临床人群中的安全性和有效性。
