Aloia J F, Vaswani A, Ellis K, Yuen K, Cohn S H
J Lab Clin Med. 1985 Dec;106(6):630-7.
Bone mass of the total skeleton and distal radius were measured by in vivo neutron activation analysis and single photon absorptiometry, respectively, in 403 healthy white women and 151 healthy white men. In addition, the density of L-2 to L-4 (bone mineral content of the spine [BMCs]) was measured by dual photon absorptiometry in 159 of these women and in 56 women with the vertebral crush fracture syndrome. The rate of loss of total body calcium (TBCa) and bone mineral content of the radius (BMCr) was linear in men and was slower than in women. The best fit for TBCa and the bone mineral content of the distal radius and spine as a function of age in women was with a two-phase regression. The TBCa and BMCr could be used as well as BMCs to identify women with crush fractures. The ratios of BMCs/TBCa, BMCs/BMCr, and TBCa/BMCr did not differ among women with crush fractures and age-matched normal individuals. Our data do not support the hypothesis that women with vertebral crush fractures have preferential loss of spinal bone.
分别采用体内中子活化分析法和单光子吸收法，对403名健康白人女性和151名健康白人男性的全身骨骼和桡骨远端骨量进行了测量。此外，还采用双能光子吸收法对其中159名女性以及56名患有椎体压缩性骨折综合征的女性的L2至L4椎体密度（脊柱骨矿物质含量[BMCs]）进行了测量。男性全身钙（TBCa）和桡骨骨矿物质含量（BMCr）的流失率呈线性，且比女性慢。女性的TBCa、桡骨远端和脊柱的骨矿物质含量与年龄的最佳拟合为两阶段回归。TBCa和BMCr以及BMCs均可用于识别患有压缩性骨折的女性。患有压缩性骨折的女性与年龄匹配的正常个体之间，BMCs/TBCa、BMCs/BMCr和TBCa/BMCr的比值并无差异。我们的数据不支持椎体压缩性骨折女性存在脊柱骨优先流失的假说。
