Carnicer-Lombarte Alejandro, Malliaras George G, Barone Damiano G
Department of Engineering, Electrical Engineering Division, University of Cambridge, Cambridge, CB3 0FA, UK.
Department of Neurosurgery, Houston Methodist, Houston, 77030, USA.
Adv Mater. 2025 Jan;37(3):e2408308. doi: 10.1002/adma.202408308. Epub 2024 Nov 20.
Biohybrid regenerative bioelectronics are an emerging technology combining implantable devices with cell transplantation. Once implanted, biohybrid regenerative devices integrate with host tissue. The combination of transplant and device provides an avenue to both replace damaged or dysfunctional tissue, and monitor or control its function with high precision. While early challenges in the fusion of the biological and technological components limited development of biohybrid regenerative technologies, progress in the field has resulted in a rapidly increasing number of applications. In this perspective the great potential of this emerging technology for the delivery of therapy is discussed, including both recent research progress and potential new directions. Then the technology barriers are discussed that will need to be addressed to unlock the full potential of biohybrid regenerative devices.
生物杂交再生生物电子学是一种将可植入设备与细胞移植相结合的新兴技术。一旦植入，生物杂交再生设备就会与宿主组织整合。移植与设备的结合为替换受损或功能失调的组织以及高精度监测或控制其功能提供了一条途径。虽然生物和技术组件融合方面的早期挑战限制了生物杂交再生技术的发展，但该领域的进展已带来了越来越多的应用。本文从这一角度探讨了这项新兴技术在治疗方面的巨大潜力，包括近期的研究进展和潜在的新方向。然后讨论了为释放生物杂交再生设备的全部潜力而需要克服的技术障碍。
