Tang Wei, Xue Haiyan, He XiaLin, Lin Sha, Fang Zhixiong
Department of Infectious Disease and Public Health, Xiangtan Central Hospital, Hunan University, Hunan, China.
Department of Traditional Chinese Medicine, Shaoshan People's Hospital, Xiangtan, China.
Diagn Microbiol Infect Dis. 2025 Nov;113(3):117001. doi: 10.1016/j.diagmicrobio.2025.117001. Epub 2025 Jul 10.
Scedosporium apiospermum, a rare but increasingly recognized fungal pathogen, poses significant diagnostic and therapeutic challenges. Traditionally associated with immunocompromised individuals. We present a case of S. apiospermum lung disease in an immunocompetent patient, initially misdiagnosed as tuberculosis due to overlapping clinical and radiological features. Accurate diagnosis was achieved through bronchoscopy and fungal culture, leading to successful treatment with antifungal therapy. This case highlights the importance of considering S. apiospermum in the differential diagnosis of refractory lung infections, even in patients without obvious risk factors. Additionally, a brief literature review sheds light on the epidemiology, clinical presentation, and treatment strategies for this pathogen, emphasizing its clinical relevance and the need for heightened awareness. By showcasing this case, we aim to contribute to the understanding of S. apiospermum lung disease and its management, inspiring further research and improving patient outcomes.
伪阿利什霉，一种罕见但越来越受到认可的真菌病原体，带来了重大的诊断和治疗挑战。传统上与免疫功能低下的个体相关。我们报告一例免疫功能正常患者的伪阿利什霉肺病病例，该患者最初因临床和影像学特征重叠而被误诊为肺结核。通过支气管镜检查和真菌培养实现了准确诊断，随后通过抗真菌治疗成功治愈。该病例强调了在难治性肺部感染的鉴别诊断中考虑伪阿利什霉的重要性，即使在没有明显危险因素的患者中也是如此。此外，一项简短的文献综述揭示了该病原体的流行病学、临床表现和治疗策略，强调了其临床相关性以及提高认识的必要性。通过展示该病例，我们旨在促进对伪阿利什霉肺病及其管理的理解，激发进一步的研究并改善患者预后。
