Jamal Doaa, AlMushayt Abdullah, Abujamel Turki, Bamashmous Shatha, Bamashmous Nada, Alamoudi Najlaa
Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
BMC Oral Health. 2025 Jul 17;25(1):1195. doi: 10.1186/s12903-025-06107-x.
Silver Diamine Fluoride (SDF) is a caries-arresting agent that gained popularity among clinicians and patients due to its effectiveness within hours of application. However, the exact mechanisms underlying its action are not yet fully understood. This narrative review explores the current knowledge of SDF's role in caries management, focusing on its mechanism of action, application methods, and safety.
A comprehensive search was conducted in PubMed, MEDLINE, ScienceDirect, and Google Scholar. Out of 820 identified studies, 40 were selected based on relevance to SDF's chemical properties and clinical application, following duplicate removal and screening of abstracts and full texts.
Although the literature provides insight into SDF's benefits in managing caries, its exact mechanism of action and long-term outcomes remain insufficiently understood. Furthermore, variations in the composition of commercially available SDF products, particularly in silver, fluoride, and pH levels, may significantly affect their clinical performance. This variability raises concerns about consistency in therapeutic outcomes and underscores the need for formulation standardization.
Understanding SDF antimicrobial and remineralization mechanisms is essential for optimizing its clinical use in caries management. While current evidence supports its efficacy, further studies are needed to standardize formulations, refine application protocols, and clarify its long-term therapeutic outcomes.
氟化亚锡（SDF）是一种防龋剂，因其在应用数小时内即可发挥作用，在临床医生和患者中颇受欢迎。然而，其确切作用机制尚未完全明确。本叙述性综述探讨了SDF在龋病管理中的作用的现有知识，重点关注其作用机制、应用方法和安全性。
在PubMed、MEDLINE、ScienceDirect和谷歌学术上进行了全面检索。在820项已识别的研究中，经过重复文献去除以及摘要和全文筛选，基于与SDF化学性质和临床应用的相关性，选择了40项研究。
尽管文献提供了SDF在龋病管理中的益处的相关见解，但其确切作用机制和长期效果仍未得到充分理解。此外，市售SDF产品成分的差异，特别是银、氟和pH值水平的差异，可能会显著影响其临床性能。这种变异性引发了对治疗效果一致性的担忧，并强调了制剂标准化的必要性。
了解SDF的抗菌和再矿化机制对于优化其在龋病管理中的临床应用至关重要。虽然目前的证据支持其疗效，但仍需要进一步研究来规范制剂、完善应用方案并阐明其长期治疗效果。
