Kern Amarett, Renteria Tammy White, Rothen Marilynn L, Mancl Lloyd A, Milgrom Peter
Inland Northwest Veterinary Dentistry and Oral Surgery, Coeur d'Alene, ID, United States.
School of Dentistry and Research Implementation Manager, Institute of Translational Health Sciences Regional Clinical Dental Research Center, University of Washington, Seattle, WA, United States.
Front Vet Sci. 2023 Sep 20;10:1255834. doi: 10.3389/fvets.2023.1255834. eCollection 2023.
Periodontal disease is a ubiquitous disease in small animal veterinary medicine. Currently regular professional dental cleaning and daily tooth brushing are considered gold standards in the prevention of periodontal disease. Efforts to find a noninvasive, cost effective and easy to use preventative for periodontal disease are ongoing. The primary objective of this double-blind randomized clinical trial was to determine if a single application of silver diamine fluoride (SDF) 38% on the buccal surface of all teeth would reduce gingivitis within 3 months in dogs with stage two periodontal disease.
Twenty-nine client-owned dogs 3-12 years old, 6-35 pounds were randomized 1:1 into active and placebo-control groups. Both groups underwent a baseline treatment and a three-month follow-up under general anesthesia. Gingival Index (GI), Plaque Index (PI), and Calculus Index (CI) were assessed and recorded at each event.
A single application of SDF 38% did not significantly lower GI relative to the control group. However, the GI score dropped significantly in both groups relative to baseline, with a 53% reduction in the average GI score for dogs that received SDF 38% treatment and a 44% reduction for dogs that received placebo treatment. There were no differences in PI or CI scores compared to control groups.
Further research is needed to determine if a more frequent application or a longer study duration would yield a different outcome.
牙周病是小动物兽医学中一种普遍存在的疾病。目前，定期进行专业牙齿清洁和每日刷牙被认为是预防牙周病的金标准。人们一直在努力寻找一种非侵入性、经济高效且易于使用的牙周病预防方法。这项双盲随机临床试验的主要目的是确定在患有二期牙周病的犬只中，在所有牙齿的颊面单次应用38%的氟化银（SDF）是否能在3个月内减轻牙龈炎。
将29只年龄在3至12岁、体重6至35磅的客户拥有的犬只按1:1随机分为活性组和安慰剂对照组。两组均在全身麻醉下接受基线治疗和为期三个月的随访。在每次检查时评估并记录牙龈指数（GI）、菌斑指数（PI）和牙石指数（CI）。
与对照组相比，单次应用38%的SDF并没有显著降低GI。然而，两组的GI评分相对于基线均显著下降，接受38% SDF治疗的犬只平均GI评分降低了53%，接受安慰剂治疗的犬只降低了44%。与对照组相比，PI或CI评分没有差异。
需要进一步研究以确定更频繁的应用或更长的研究持续时间是否会产生不同的结果。
