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评估心脏直视手术快速康复策略的安全性、可行性及临床结局。

Assessing the Safety, Feasibility, and Clinical Outcomes of a Fast-Track Strategy in Open Cardiac Surgery.

作者信息

Sundström Anna, Larsson Mark, Falk Anna, Stenman Malin, Campoccia Jalde Francesca, Dalén Magnus, Fredby Magnus, Sartipy Ulrik, Nordberg Per

机构信息

Function Perioperative Medicine and Intensive Care, Section for Cardiothoracic Anesthesia and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Eur J Cardiothorac Surg. 2025 Aug 1;67(8). doi: 10.1093/ejcts/ezaf238.

Abstract

OBJECTIVES

To study feasibility, safety, and clinical outcomes after the implementation of a fast-track concept after open cardiac surgery.

METHODS

A single-centre observational study (2018-2023) using data from the cardiothoracic intensive care unit (ICU) registry at the Karolinska University Hospital and the SWEDEHEART registry. The fast-track intervention included immediate extubation, early and frequent mobilization, prompt oral intake, and transfer to regular ward the day after surgery. Main outcomes were proportion of patients discharged to regular ward on the first postoperative day, length of hospital stay, and 30-day mortality.

RESULTS

Totally, 5234 open cardiac procedures were performed, of which 2801 patients (78% men, median age 63 years SD 12.3, mean EuroSCORE II 2.0 SD 2.0) were treated at the fast-track unit. The most common procedures were coronary artery bypass grafting (CABG, 42.4%) and single non-CABG procedure (37.5%). In total, 94.6% (n = 2649) of patients were discharged the day after surgery. Of those requiring ICU care (n = 152), circulatory failure (n = 57) and reoperation due to bleeding or tamponade (n = 51) were most frequent. Patients with fast-track failure had a EuroSCORE II of 2.9 vs 1.9 in discharged patients (P < 0.001). Median hospital stay was 5 days for patients discharged as planned, compared to 8.7 days for those transferred to ICU (P < 0.001). The 30-day mortality was 0.3%, with 0.2% in patients discharged as planned and 1.3% in those requiring ICU transfer (P = 0.096).

CONCLUSIONS

Following the fast-track implementation after open cardiac surgery, approximately 95% of patients were discharged the day after surgery, with a 30-day mortality rate of 0.3%.

摘要

目的

研究心脏直视手术后实施快速康复理念的可行性、安全性及临床结局。

方法

一项单中心观察性研究(2018 - 2023年),使用卡罗林斯卡大学医院心胸重症监护病房(ICU)登记处的数据以及瑞典心脏注册研究(SWEDEHEART)的数据。快速康复干预措施包括即刻拔管、早期且频繁的活动、术后及时经口进食以及术后第一天转至普通病房。主要结局指标为术后第一天转至普通病房的患者比例、住院时间及30天死亡率。

结果

共进行了5234例心脏直视手术,其中2801例患者(78%为男性,中位年龄63岁,标准差12.3,欧洲心脏手术风险评估系统II(EuroSCORE II)平均评分为2.0,标准差2.0)在快速康复病房接受治疗。最常见的手术为冠状动脉旁路移植术(CABG,42.4%)和非CABG单台手术(37.5%)。总共有94.6%(n = 2649)的患者在术后第一天出院。在那些需要重症监护的患者中(n = 152),循环衰竭(n = 57)以及因出血或心包填塞而再次手术(n = 51)最为常见。快速康复失败的患者EuroSCORE II评分为2.9,而出院患者为1.9(P < 0.001)。按计划出院的患者中位住院时间为5天,而转至ICU的患者为8.7天(P < 0.001)。30天死亡率为0.3%,按计划出院的患者为0.2%,需要转至ICU的患者为1.3%(P = 0.096)。

结论

心脏直视手术后实施快速康复方案后,约95%的患者在术后第一天出院,30天死亡率为0.3%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43e4/12317742/0bb906fb4950/ezaf238f3.jpg

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