Reda Fayiz M, Alawam Abdullah S, Mahmoud Hemat K, El-Saadony Mohamed T, Salah Ayman S, Rudayni Hassan A, Allam Ahmed A, El-Naggar Karima, Alagawany Mahmoud, Khairunnesa Most
Poultry Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Vet Med Sci. 2025 Jul;11(4):e70508. doi: 10.1002/vms3.70508.
Nanoparticles (NPs), such as green cobalt NPs (CoNPs), are easier to pass through cell membranes in animals and interact rapidly with biological systems. Therefore, using green CoNPs is one of the recommendations for enhancing the bioavailability of cobalt, thereby improving its absorption.
The goal of this study was to explore the influences of biological nano-cobalt (BNCo) as a feed supplement on broiler growth performance, haematology, blood chemistry, antioxidant activities, immunological status, digestive enzymes and carcass characteristics.
A total of 300 Arbour Acre broiler chicks, all unsexed, were distributed into 5 treatment groups, each containing 60 chicks, at random. Five replications of each group were formed, each containing 12 chicks. The first group received a control diet free of BNCo, whereas the second, third, fourth and fifth groups were administered diets fortified with BNCo at concentrations of 100, 200, 300 and 400 ppm, respectively.
The results illustrated a significant increase in body weight (p < 0.001), body weight gain (p < 0.001) and improvement in feed conversion ratio (p < 0.01) in comparison to the control diet. BNCo supplementation significantly increased the percentage of immune organs, especially the spleen and thymus (p < 0.05, p < 0.01). Moreover, BNCo supplementation significantly increased haemoglobin (Hb) (p < 0.01), red blood cells (RBCs) (p < 0.05) and white blood cells (WBCs) (p < 0.05). In broiler chickens, BNCo supplementation increased serum levels of total protein, albumin and globulin significantly (p < 0.05) and reduced serum levels of aspartate aminotransferase (AST) activity (p < 0.001) and alanine aminotransaminase (ALT) (p < 0.01). The BNCo in feed supplementation raised blood levels of cobalt and markedly improved lipid markers, immunological and antioxidant status (p < 0.05). Furthermore, digestive enzymes were significantly boosted (p < 0.05) by BNCo treatments.
The results indicated that BNCo supplementation at 200 ppm/kg diet produced the best overall performance, demonstrating its potential as an innovative additive for broiler diets.
纳米颗粒（NPs），如绿色钴纳米颗粒（CoNPs），在动物体内更容易穿过细胞膜并与生物系统迅速相互作用。因此，使用绿色CoNPs是提高钴生物利用度从而改善其吸收的建议之一。
本研究的目的是探讨作为饲料添加剂的生物纳米钴（BNCo）对肉鸡生长性能、血液学、血液生化、抗氧化活性、免疫状态、消化酶和胴体特性的影响。
总共300只未区分性别的 Arbor Acre 肉鸡随机分为5个处理组，每组60只鸡。每组形成5个重复，每个重复包含12只鸡。第一组接受不含BNCo的对照日粮，而第二、第三、第四和第五组分别给予添加浓度为100、200、300和400 ppm BNCo的日粮。
结果表明，与对照日粮相比，体重（p < 0.001）、体重增加（p < 0.001）显著增加，饲料转化率提高（p < 0.01）。补充BNCo显著提高了免疫器官的百分比，尤其是脾脏和胸腺（p < 0.05，p < 0.01）。此外，补充BNCo显著增加了血红蛋白（Hb）（p < 0.01）、红细胞（RBCs）（p < 0.05）和白细胞（WBCs）（p < 0.05）。在肉鸡中，补充BNCo显著提高了血清总蛋白、白蛋白和球蛋白水平（p < 0.05），并降低了血清天冬氨酸转氨酶（AST）活性（p < 0.001）和丙氨酸转氨酶（ALT）（p < 0.01）。饲料中补充BNCo提高了血液中钴的水平，并显著改善了脂质指标、免疫和抗氧化状态（p < 0.05）。此外，BNCo处理显著提高了消化酶活性（p < 0.
