Fujiwara-Igarashi Aki, Goto Sho, Ohshima Takafumi, Sakanoue Shota, Taniguchi Tetsuya, Tetsu Haruyoshi, Nakazawa Yuta, Endo Yasuyuki
Laboratory of Veterinary Radiology, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan.
Laboratory of Small Animal Internal Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
J Feline Med Surg. 2025 Jul;27(7):1098612X251340050. doi: 10.1177/1098612X251340050. Epub 2025 Jul 18.
ObjectivesThis study aimed to evaluate factors associated with recurrence of clinical signs after balloon dilation in cats with nasopharyngeal stenosis (NPS).MethodsA retrospective multicentre study was conducted using data collected from the medical records of cats treated for NPS using balloon dilation. A total of 47 cats, each with a follow-up period of ⩾180 days, were included in the analysis of progression-free interval (PFI) and hazard ratio (HR) using Kaplan-Meier and Cox proportional hazards analyses.ResultsMultiple balloon dilations were planned for 26/47 cats. In total, 14 cats received three procedures and 12 cats received two. The dilations were performed at a median interval of 35 days (interquartile range [IQR] 29-39, range 15-127), regardless of transient recurrence. A single dilation was planned for the remaining 21 cats. Recurrence after the final balloon dilation occurred in 18/47 (38%) cats; in these cases, the median time from the final dilation to recurrence was 42 days (IQR 18-142, range 6-2303). The median PFI was 2303 days (range 6-2704), with 6-month and 1-year recurrence-free rates of 70% and 65%, respectively. Multivariate analysis revealed that performing planned multiple dilations was the only variable associated with improved PFI (HR 0.06, 95% confidence interval [CI] 0.01-0.30; < 0.001). Specifically, cats undergoing planned multiple dilations had higher 6-month (92% vs 43%) and 1-year (88% vs 38%) progression-free rates than those undergoing a single dilation. No significant correlation was observed between PFI and the number of balloon dilation treatments.Conclusions and relevanceBalloon dilation repeated two or three times, regardless of any recurrence of signs, may assist in the long-term resolution of NPS in some cases.
目的
本研究旨在评估与鼻咽狭窄（NPS）猫球囊扩张术后临床症状复发相关的因素。
方法
采用回顾性多中心研究，收集接受球囊扩张治疗NPS的猫的病历数据。共47只猫，每只猫的随访期均≥180天，采用Kaplan-Meier法和Cox比例风险分析法对无进展生存期（PFI）和风险比（HR）进行分析。
结果
计划对26/47只猫进行多次球囊扩张。总共，14只猫接受了三次手术，12只猫接受了两次手术。无论是否有短暂复发，扩张的中位间隔时间为35天（四分位间距[IQR]29 - 39，范围15 - 127）。计划对其余21只猫进行单次扩张。最终球囊扩张术后，18/47（38%）只猫出现复发；在这些病例中，从最终扩张到复发的中位时间为42天（IQR 18 - 142，范围6 - 2303）。中位PFI为2303天（范围6 - 2704），6个月和1年的无复发率分别为70%和65%。多变量分析显示，进行计划好的多次扩张是与改善PFI相关的唯一变量（HR 0.06，95%置信区间[CI]0.01 - 0.30；P < 0.001）。具体而言，接受计划好的多次扩张的猫的6个月（92%对43%）和1年（88%对38%）无进展率高于接受单次扩张的猫。未观察到PFI与球囊扩张治疗次数之间存在显著相关性。
结论及意义
在某些情况下，无论症状是否复发，重复进行两到三次球囊扩张可能有助于NPS的长期缓解。
