Neto Sebastião Gonçalves de Barros, de Araújo Catherine Oliveira, Reis Renandro de Carvaho, Almeida Kelson James da Silva, Brunoni Decio, Cysneiros Roberta Monterazzo
Laboratory of Neurobiology, Mackenzie Presbyterian University. Rua da Consolação, 930 - prédio 28, 10 andar - São Paulo- SP, CEP 04048061, Brazil.
Pharmaceutical Science Postgraduate Program. Federal University of Piaui. Teresina - PI, Brazil.
Data Brief. 2025 Jun 18;61:111802. doi: 10.1016/j.dib.2025.111802. eCollection 2025 Aug.
Pharmacological interventions are widely used in autism spectrum disorder (ASD). We investigated the profile of psychopharmaceutical in a sample of children with ASD of low socioeconomic stratum enrolled and the public school in the city of Embu das Artes, Sao Paulo Brazil. From 149 children with a diagnosis of ASD identified in the municipal education department, informant consents were obtained from 129 children's parents. Data collection was performed through clinical evaluation of the children and face to face application of a questionnaire for parents regarding medication use. The participants socioeconomic stratum was mostly C (72.86 %), followed by B (16,27 %), D (10.07 %), and A (0.7 %) who do not undergo specialized multi-professional educational and behavioral intervention. Among the participants 57.36 % were under psychopharmacological intervention and 33.78 % were under a polypharmacy regimen. Typical antipsychotics were used for 35.4 % followed by atypical antipsychotics (27.43 %), antiseizure (19.47 %), and tricyclic antidepressants (7.08 %). The association of risperidone with valproic acid prevailed in 17.68 % of the sample. ASD levels 2 and 3, epilepsy and age were associated with a higher rate of psychopharmaceutical use. The present dataset can be used to investigate the rational use of medication in the ASD population to monitor potential adverse effects, and to compare with the ASD population across the world
药物干预在自闭症谱系障碍(ASD)中被广泛应用。我们调查了巴西圣保罗州恩布达斯阿尔蒂斯市一所公立学校中低收入阶层自闭症谱系障碍儿童样本的精神药物使用情况。在市教育部门确定的149名自闭症谱系障碍儿童中,获得了129名儿童家长的知情同意。通过对儿童的临床评估以及向家长面对面发放关于用药情况的问卷来进行数据收集。参与者的社会经济阶层大多为C类(72.86%),其次是B类(16.27%)、D类(10.07%)和A类(0.7%),这些儿童未接受专门的多专业教育和行为干预。在参与者中,57.36%接受精神药物干预,33.78%接受联合用药方案。典型抗精神病药物的使用比例为35.4%,其次是非典型抗精神病药物(27.43%)、抗癫痫药物(19.47%)和三环类抗抑郁药(7.08%)。利培酮与丙戊酸联合使用在样本中的占比为17.68%。ASD 2级和3级、癫痫和年龄与精神药物的较高使用率相关。本数据集可用于研究自闭症谱系障碍人群药物的合理使用,监测潜在不良反应,并与全球自闭症谱系障碍人群进行比较。