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对乙酰氨基酚中毒：肝损伤早期肝脏透析的病例报告

Acetaminophen Poisoning: Case Reports of Early Liver Dialysis for Hepatic Injury.

作者信息

Rahimi Mitra, Shadnia Shahin, Mostafazadeh Babak, Evini Peyman Erfan Talab, Hosseini Sayed Masoud, Deravi Niloofar, Belbasi Mohaddeseh

机构信息

Toxicological Research Center, Excellence Center of Clinical Toxicology, Department of Clinical Toxicology, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran.

Students Research Committee Shahid Beheshti University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2025 Jul 17;13(7):e70642. doi: 10.1002/ccr3.70642. eCollection 2025 Jul.

DOI:10.1002/ccr3.70642
PMID:40677300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12268227/
Abstract

In acetaminophen-induced acute liver failure, early use of extracorporeal artificial liver support using BS330/HA330-II filters improves liver function, coagulation profiles, bilirubin levels, and may obviate the need for liver transplantation. Early adjunctive use with N-acetylcysteine may optimize outcomes; further studies are necessary to confirm efficacy, safety, and standardized protocols.

摘要

在对乙酰氨基酚所致急性肝衰竭中，早期使用采用BS330/HA330-II滤器的体外人工肝支持可改善肝功能、凝血指标、胆红素水平，并可能避免肝移植的需要。早期与N-乙酰半胱氨酸联合使用可能使治疗效果最优化；有必要开展进一步研究以证实其疗效、安全性及标准化方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/a1ab226213ba/CCR3-13-e70642-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/973141fbf53c/CCR3-13-e70642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/dea0de167095/CCR3-13-e70642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/a1ab226213ba/CCR3-13-e70642-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/973141fbf53c/CCR3-13-e70642-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/dea0de167095/CCR3-13-e70642-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60a1/12268227/a1ab226213ba/CCR3-13-e70642-g003.jpg

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本文引用的文献

1
Association between volume of processed plasma and total bilirubin reduction during plasma adsorption for severe liver disease.重症肝病血浆吸附过程中处理血浆量与总胆红素降低之间的关联
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Hemoperfusion with the HA330/HA380 Cartridge in Intensive Care Settings: A State-Of-The-Art Review.重症监护环境中使用HA330/HA380血液灌流器：最新综述
Blood Purif. 2025;54(2):122-137. doi: 10.1159/000542469. Epub 2024 Nov 21.
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Late -acetylcysteine for successful recovery of acetaminophen-related acute liver failure: A case report.
晚期使用乙酰半胱氨酸成功救治对乙酰氨基酚相关急性肝衰竭：一例报告
Clin Case Rep. 2023 Sep 25;11(9):e7946. doi: 10.1002/ccr3.7946. eCollection 2023 Sep.
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Colchicine poisoning treated with hemoperfusion and hemodialysis: A case report.血液灌流和血液透析治疗秋水仙碱中毒：一例报告。
Clin Case Rep. 2022 Oct 7;10(10):e6419. doi: 10.1002/ccr3.6419. eCollection 2022 Oct.
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Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram.利用 Rumack-Matthew 列线图评估急性对乙酰氨基酚过量的剂量估计值对预测肝毒性风险的敏感性。
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BMJ Open. 2021 Dec 14;11(12):e047690. doi: 10.1136/bmjopen-2020-047690.
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Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.使用非那西丁（4-甲基吡唑）治疗对乙酰氨基酚中毒：范围综述。
Toxicol Lett. 2022 Feb 1;355:47-61. doi: 10.1016/j.toxlet.2021.11.005. Epub 2021 Nov 14.
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Case Series: Efficacy and Safety of Hemoadsorption With HA-330 Adsorber in Septic Pediatric Patients With Cancer.病例系列：HA-330吸附器血液吸附在患有癌症的脓毒症儿科患者中的疗效和安全性
Front Pediatr. 2021 Jun 11;9:672260. doi: 10.3389/fped.2021.672260. eCollection 2021.
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[Application of double plasma molecular adsorption system in children with acute liver failure].双重血浆分子吸附系统在儿童急性肝衰竭中的应用
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Comparison of plasma exchange, double plasma molecular adsorption system, and their combination in treating acute-on-chronic liver failure.血浆置换、双重血浆分子吸附系统及其联合治疗慢加急性肝衰竭的比较。
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