Sakaeyama Yuki, Fuchinoue Yutaka, Nemoto Masaaki, Matsuzaki Ryo, Kubota Shuhei, Abe Mitsuyoshi, Terazono Sayaka, Sugo Nobuo
Neurosurgery, Toho University, Tokyo, JPN.
Neurosurgery (Sakura), Toho University, Chiba, JPN.
Cureus. 2025 Jun 15;17(6):e86097. doi: 10.7759/cureus.86097. eCollection 2025 Jun.
Introduction Seasonal variations have been proposed as potential contributors to the risk of cerebral aneurysm rupture. The Unruptured Cerebral Aneurysm Study of Japan (UCAS Japan) score is a validated tool to assess the risk of aneurysm rupture, incorporating six factors: age, sex, hypertension, aneurysm size, location, and the presence of a daughter sac. Risk stratification is as follows: 0-3 (Risk I; 3-year rupture rate, 0.2%-0.9%), 4-5 (Risk II; 1.4%-2.3%), 6-8 (Risk III; 3.7%-7.6%), and ≥9 (Risk IV; ≥17%). This study investigates the association between meteorological conditions and the occurrence of subarachnoid hemorrhage (SAH) due to aneurysm rupture, with patients' risk levels categorized according to their UCAS Japan scores. Methods This study included 137 patients diagnosed with SAH who were admitted to our hospital between January 2014 and December 2023. Meteorological variables, including temperature, atmospheric pressure, and precipitation, were analyzed to examine their association with the onset of SAH. Results The temperature difference between one day before onset and the day of onset was significantly greater in Group IV compared to Group II (p< 0.05). Additionally, the temperature differences between the day of onset and 1, 2, and 3 days before onset were significantly larger in Group IV than in Group III (p< 0.01, p < 0.01, and p < 0.05, respectively). The temperature difference between the day of onset and 1, 2, and 3 days before onset was significantly larger in Group IV than in Groups I, II, and III (p < 0.01). No significant differences were observed among the groups in terms of atmospheric pressure, precipitation, or seasonal variation. Conclusion Temperature drops are associated with SAH onset in patients with high-risk aneurysms. This study highlights the importance of considering weather-related factors, particularly temperature fluctuations, when assessing the risk of aneurysm rupture. Further research is warranted to validate these findings.
引言 季节性变化被认为是导致脑动脉瘤破裂风险的潜在因素。日本未破裂脑动脉瘤研究（UCAS Japan）评分是一种经过验证的评估动脉瘤破裂风险的工具，纳入了六个因素：年龄、性别、高血压、动脉瘤大小、位置以及是否存在子囊。风险分层如下：0 - 3分（风险I；3年破裂率，0.2% - 0.9%），4 - 5分（风险II；1.4% - 2.3%），6 - 8分（风险III；3.7% - 7.6%），以及≥9分（风险IV；≥17%）。本研究调查气象条件与因动脉瘤破裂导致的蛛网膜下腔出血（SAH）发生之间的关联，并根据患者的UCAS Japan评分对其风险水平进行分类。方法 本研究纳入了2014年1月至2023年12月期间在我院住院的137例诊断为SAH的患者。分析了包括温度、气压和降水量在内的气象变量，以检查它们与SAH发病的关联。结果 与II组相比，IV组发病前一天与发病当天的温差显著更大（p < 0.05）。此外，IV组发病当天与发病前1天、2天和3天的温差显著大于III组（分别为p < 0.01、p < 0.01和p < 0.05）。IV组发病当天与发病前1天、2天和3天的温差显著大于I组、II组和III组（p < 0.01）。在气压、降水量或季节变化方面，各组之间未观察到显著差异。结论 温度下降与高危动脉瘤患者的SAH发病相关。本研究强调了在评估动脉瘤破裂风险时考虑与天气相关因素，特别是温度波动的重要性。有必要进行进一步研究以验证这些发现。
