Stegink L D, Pitkin R M
Am J Clin Nutr. 1977 Jul;30(7):1087-93. doi: 10.1093/ajcn/30.7.1087.
Intravenous infusion of glucose-amino acid complexes, formed during heat sterilization of mixtures of glucose and amino acids or protein hydrolysates, has been associated with mild dehydration in infants, and with excessive trace metal ion excretion in both infants and adults. When parenteral solutions containing these glucose-amino acid complexes were infused into pregnant rhesus monkeys, the compounds accumlated in the maternal plasma and were transported to the fetal circulation. Although all of the compounds studied crossed the placenta, fetal levels were consistently lower than maternal levels. Amniotic fluid concentrations of these compounds increased progressively with the length of maternal infusion, presumably through fetal urination into the amniotic sac. In animals infused with solutions not heat sterilized, levels of these compounds could not be detected in maternal plasma and urine, fetal plasma and urine, or in amniotic fluid. In view of possible toxicity of the glucose-amino acid complexes, parenteral solutions containing these compounds should probably be avoided in the intravenous nutrition of the pregnant woman.
葡萄糖和氨基酸或蛋白质水解产物混合物在热灭菌过程中形成的葡萄糖 - 氨基酸复合物静脉输注，已被证实与婴儿轻度脱水以及婴儿和成人过量的微量金属离子排泄有关。当将含有这些葡萄糖 - 氨基酸复合物的肠外溶液输注到怀孕的恒河猴体内时，这些化合物在母体血浆中积累并被转运到胎儿循环中。尽管所研究的所有化合物都能穿过胎盘，但胎儿体内的水平始终低于母体水平。这些化合物在羊水中的浓度随着母体输注时间的延长而逐渐增加，推测是通过胎儿排尿进入羊膜囊所致。在输注未经过热灭菌溶液的动物中，在母体血浆和尿液、胎儿血浆和尿液或羊水中均未检测到这些化合物的存在。鉴于葡萄糖 - 氨基酸复合物可能具有的毒性，在孕妇的静脉营养中可能应避免使用含有这些化合物的肠外溶液。
