Tang Yaodong, Zhao Peinan, Cheng Allen C, Ibrahim Aaliya, Hassall Jenna, Litton Edward, Andersen Christopher R, Liang Cindy, Milford Elissa M, Rose Morgan, Plummer Mark, Kong Jing, Johnson Kerry, Bihari Shailesh, Chaba Anis, Begum Husna, Cruz Sherene Magana, Ng Sze, Trapani Tony, Campbell Lewis, Ramanan Mahesh, McAllister Richard, Chumbes Jenipher, Erickson Simon, Kol Mark, Cheung Winston, Udy Andrew A, Burrell Aidan
Department of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Melbourne, VIC, Australia.
Department of Intensive Care Medicine, The Austin Hospital, Melbourne, VIC, Australia.
Crit Care Resusc. 2025 Jun 27;27(2):100113. doi: 10.1016/j.ccrj.2025.100113. eCollection 2025 Jun.
To assess the characteristics, treatments and outcomes of paediatric and adult intensive care unit (ICU) patients with respiratory syncytial virus (RSV) infection, and compare these with coronavirus disease (COVID-19) during the same period.
We conducted a multicenter, prospective, observational study using data from the short period incidence study of severe acute respiratory infection (SPRINT SARI) Australia, in 38 Australian ICUs from 1 June 2022 to 1 September 2024. Demographic, treatment, and outcome data were analysed for patients with confirmed RSV or COVID-19. The primary outcome was in-hospital mortality.
Of 4693 patients were recorded in the SPRINT-SARI database, 2540 met inclusion criteria. RSV was more common in paediatric patients (410/620, 62%) than in adults (249/1920, 13%). Adult with RSV had more chronic pulmonary conditions than those with COVID-19. Paediatric patients with RSV had fewer comorbidities and less invasive mechanical ventilation (IMV) compared to those with COVID-19 (P < 0.05), but required longer duration of IMV once intubated. In-hospital mortality was similar for both adult RSV and COVID-19 (36/249, 14.5%) vs (260/1671, 15.6%), and paediatric RSV(3/410 [0.7%] vs 7/210 [3.3%] P = 0.07). Mortality in adults was associated with male sex, older age, comorbidities, and IMV. Mortality in children was associated with IMV only.
RSV infection can result in an attributable number of ICU admission in Australia, especially in specific populations including young children and older adults with respiratory comorbidities. Mortality in patients admitted to ICU is similar to COVID-19.
评估感染呼吸道合胞病毒（RSV）的儿科和成人重症监护病房（ICU）患者的特征、治疗方法及预后，并与同期的冠状病毒病（COVID-19）患者进行比较。
设计、地点和参与者：我们利用澳大利亚严重急性呼吸道感染短期发病率研究（SPRINT SARI）的数据，于2022年6月1日至2024年9月1日在澳大利亚38个ICU进行了一项多中心、前瞻性观察性研究。对确诊为RSV或COVID-19的患者的人口统计学、治疗及预后数据进行分析。主要结局指标为院内死亡率。
在SPRINT-SARI数据库记录的4693例患者中，2540例符合纳入标准。RSV在儿科患者中（410/620，62%）比在成人中（249/1920，13%）更常见。感染RSV的成人比感染COVID-19的成人有更多慢性肺部疾病。与感染COVID-19的儿科患者相比，感染RSV的儿科患者合并症更少，有创机械通气（IMV）使用更少（P<0.05），但插管后IMV持续时间更长。成人RSV和COVID-19患者的院内死亡率相似（36/249，14.5%）对比（260/1671，15.6%），儿科RSV患者（3/410 [0.7%]对比7/210 [3.3%]，P = 0.07）。成人死亡率与男性、年龄较大、合并症及IMV有关。儿童死亡率仅与IMV有关。
在澳大利亚，RSV感染可导致一定数量的ICU入院病例，尤其是在包括患有呼吸道合并症的幼儿和老年人在内的特定人群中。入住ICU患者的死亡率与COVID-19相似。
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