Mustafa Manahil, Karmazyn Boaz, Chen Diane W, Eugster Erica A
Department of Pediatrics, Division of Endocrinology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Radiology and Imaging Sciences, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana.
AACE Endocrinol Diabetes. 2025 Apr 10;12(1):46-49. doi: 10.1016/j.aed.2025.02.002. eCollection 2025 May-Jun.
BACKGROUND/OBJECTIVE: Triple ectopic thyroid is exceedingly rare. The objective of this report is to present a case of triple ectopic thyroid that presented as a right submandibular mass in a euthyroid child.
A 4-year-old boy presented with a right-sided neck mass for 2 months. Neck ultrasound revealed a soft tissue mass adjacent to the submandibular salivary gland. Post intravenous contrast computed tomography scan, an additional 2 enhancing nodules were identified in the sublingual and hyoid areas. No thyroid tissue was identified in its normal pretracheal region. A fine-needle aspiration biopsy under ultrasound guidance of the right neck mass revealed numerous follicular epithelial cells in a background of homogenous colloid, characteristic of normal thyroid tissue. A Tc-99m pertechnetate thyroid scan demonstrated that the other 2 nodules were also ectopic thyroid tissue. Further workup revealed a thyroid stimulating hormone of 6.19 mIU/L (0.7-6.4) and a free thyroxine level of 1.0 ng/dL (0.8-2.0).
Delayed presentation of ectopic thyroid tissue as a mass presents diagnostic challenges, particularly when it is not found around the course of the thyroglossal duct and is associated with 2 additional ectopic thyroid nodules. Very few cases of triple thyroid ectopy have been reported particularly in pediatric patients.
Although most cases of ectopic thyroid in children are identified shortly after birth, a late presentation can occur. In a euthyroid patient presenting with a mass and absence of a thyroid gland in the normal position, thyroid ectopy should be included in the differential diagnosis.
背景/目的:三重异位甲状腺极为罕见。本报告的目的是呈现一例三重异位甲状腺病例,该病例表现为一名甲状腺功能正常儿童的右侧颌下肿块。
一名4岁男孩出现右侧颈部肿块2个月。颈部超声显示颌下唾液腺旁有一软组织肿块。静脉注射造影剂后进行计算机断层扫描,在舌下和舌骨区域又发现了2个强化结节。在正常气管前区域未发现甲状腺组织。在超声引导下对右侧颈部肿块进行细针穿刺活检,结果显示在均匀胶体背景中有大量滤泡上皮细胞,这是正常甲状腺组织的特征。锝-99m高锝酸盐甲状腺扫描显示另外2个结节也是异位甲状腺组织。进一步检查发现促甲状腺激素为6.19 mIU/L(0.7 - 6.4),游离甲状腺素水平为1.0 ng/dL(0.8 - 2.0)。
异位甲状腺组织以肿块形式延迟出现带来了诊断挑战,尤其是当它不在甲状舌管行程周围发现且伴有另外2个异位甲状腺结节时。三重甲状腺异位的病例报道极少,尤其是在儿科患者中。
虽然大多数儿童异位甲状腺病例在出生后不久就被发现,但也可能出现延迟表现。对于甲状腺功能正常且出现肿块但正常位置无甲状腺的患者,鉴别诊断应包括甲状腺异位。