Layrisse M, Martínez-Torres C
Am J Clin Nutr. 1977 Jul;30(7):1166-74. doi: 10.1093/ajcn/30.7.1166.
Fe(III)-EDTA as iron fortification presents several advantages over the other iron salts previously used including ferrous sulfate. This iron compound exchange completely with vegetable food iron in the lumen of the gut but with the characteristics that the absorption from both, extrinsic and intrinsic food iron, is higher than that expected from other iron salfs. The comparison between the iron absorption from Fe(III)-EDTA and ferrous sulfate as iron fortification indicates that the absorption form EDTA is about twice as high than that observed from ferrous sulfate. The data indicates that only 10 to 15 mg of iron as Fe(III)-EDTA as iron fortification would be necessary to prevent iron deficiency anemia in population relying their subsistence of vegetable food only and free of parastic infection producing blood loss.
作为铁强化剂,乙二胺四乙酸铁(III)(Fe(III)-EDTA)相对于之前使用的其他铁盐(包括硫酸亚铁)具有多个优势。这种铁化合物在肠道腔内与植物性食物中的铁完全交换,但其特点是,无论是外源性还是内源性食物铁的吸收都高于其他铁盐预期的吸收量。作为铁强化剂,Fe(III)-EDTA与硫酸亚铁的铁吸收比较表明,EDTA的吸收量约为硫酸亚铁的两倍。数据表明,对于仅以植物性食物为生且无导致失血的寄生虫感染的人群,仅需10至15毫克作为铁强化剂的Fe(III)-EDTA铁就能预防缺铁性贫血。