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纤维蛋白原与白蛋白比值在妇科癌症患者中的预后作用：一项荟萃分析

Prognostic role of fibrinogen-to-albumin ratio in patients with gynecological cancers: a meta-analysis.

作者信息

Chen Yaping, Zhang Jiliang

机构信息

Clinical Laboratory, Maternal and Child Health Hospital of Changxing County, Huzhou, Zhejiang, China.

Clinical Laboratory, Lishui People's Hospital, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China.

出版信息

Front Oncol. 2025 Jul 3;15:1580940. doi: 10.3389/fonc.2025.1580940. eCollection 2025.

DOI:10.3389/fonc.2025.1580940
PMID:40678069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12267011/
Abstract

BACKGROUND

Fibrinogen-to-albumin ratio (FAR) has been widely studied for its prognostic value in gynecological cancers, but the results remain inconsistent. Therefore, this study aimed to evaluate the precise prognostic significance of FAR in gynecological cancers.

METHODS

A comprehensive literature search was conducted in PubMed, Web of Science, Embase, the Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases up to 12 May 2025. The prognostic value of FAR for overall survival (OS) and progression-free survival (PFS) in gynecological cancers was examined using pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).

RESULTS

A total of 10 articles comprising 1,902 patients were included in this meta-analysis. Pooled results indicated that elevated FAR was significantly associated with poor OS (HR = 2.75, 95% CI: 2.26-3.36, < 0.001) and shorter PFS (HR = 1.60, 95% CI: 1.20-2.12, = 0.001) in patients with gynecological cancers. Subgroup analyses confirmed that FAR predicted OS regardless of sample size, cancer type, FIGO stage, treatment modality, FAR threshold, threshold determination method, or type of survival analysis ( < 0.05). Additionally, FAR remained a significant predictor of poor PFS across different cancer types.

CONCLUSION

This meta-analysis showed that a high FAR is significantly associated with worse OS and PFS in patients with gynecological cancers. FAR may serve as a promising prognostic biomarker in clinical practice.

SYSTEMATIC REVIEW REGISTRATION

https://inplasy.com/inplasy-2025-5-0036/, identifier INPLASY202550036.

摘要

背景

纤维蛋白原与白蛋白比值（FAR）在妇科癌症中的预后价值已得到广泛研究，但结果仍不一致。因此，本研究旨在评估FAR在妇科癌症中的确切预后意义。

方法

截至2025年5月12日，在PubMed、Web of Science、Embase、Cochrane图书馆和中国知网（CNKI）数据库中进行了全面的文献检索。使用合并风险比（HR）和相应的95%置信区间（CI）来检验FAR对妇科癌症患者总生存期（OS）和无进展生存期（PFS）的预后价值。

结果

本荟萃分析共纳入10篇文章，涉及1902例患者。汇总结果表明，FAR升高与妇科癌症患者较差的OS（HR = 2.75，95% CI：2.26 - 3.36，P < 0.001）和较短的PFS（HR = 1.60，95% CI：1.20 - 2.12，P = 0.001）显著相关。亚组分析证实，无论样本量、癌症类型、国际妇产科联盟（FIGO）分期、治疗方式、FAR阈值、阈值确定方法或生存分析类型如何，FAR都能预测OS（P < 0.05）。此外，FAR在不同癌症类型中仍是PFS较差的显著预测指标。

结论

本荟萃分析表明，高FAR与妇科癌症患者较差的OS和PFS显著相关。FAR可能成为临床实践中有前景的预后生物标志物。

系统评价注册

https://inplasy.com/inplasy-2025-5-0036/，标识符INPLASY202550036

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/26bfebffb5b6/fonc-15-1580940-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/92f09cf89f6a/fonc-15-1580940-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/93d589cdaf92/fonc-15-1580940-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/83ca3aee1d85/fonc-15-1580940-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/73db5253d5a8/fonc-15-1580940-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/26bfebffb5b6/fonc-15-1580940-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/92f09cf89f6a/fonc-15-1580940-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/93d589cdaf92/fonc-15-1580940-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/83ca3aee1d85/fonc-15-1580940-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/73db5253d5a8/fonc-15-1580940-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da30/12267011/26bfebffb5b6/fonc-15-1580940-g005.jpg

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