Department of Otolaryngology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, 362000, China.
Department of Ophthalmology, Shaowu Municipal Hospital of Fujian Province, Shaowu, Nanping, Fujian, 354000, China.
BMC Cancer. 2024 Oct 11;24(1):1265. doi: 10.1186/s12885-024-13039-2.
This study aims to investigate how the impact of preoperative sarcopenia and inflammatory markers for laryngeal cancer patients and develop a new scoring system to predict their prognosis.
Patients who underwent laryngectomy for laryngeal cancer (LC) from December 2015 to December 2020 at the Second Affiliated Hospital of Fujian Medical University were included. Independent prognostic factors were determined using univariate and multivariate analyses. A new scoring system (SFAR) was established based on FAR and preoperative sarcopenia, and statistically analyzed.
198 cases included in this study that met the admission criteria. Multivariate analysis shown that preoperative sarcopenia, pTNM stage, and FAR were independent prognostic factors for laryngeal cancer. Based on these three indicators, we developed the SFAR scoring system. Multivariate analysis showed that SFAR was an independent predictor of laryngeal cancer (p < 0.001). SFAR was then incorporated into a prognostic model that included T-stage and N-stage, and a column-line graph was generated to accurately predict its survival.
Systemic inflammation and sarcopenia are significantly associated with postoperative prognosis in laryngeal cancer. A new scoring system (SFAR) had implications for improving the prognosis of patients undergoing surgery for laryngeal cancer.
本研究旨在探讨术前肌少症和炎症标志物对喉癌患者的影响，并建立新的评分系统来预测其预后。
纳入 2015 年 12 月至 2020 年 12 月在福建医科大学附属第二医院行喉切除术的喉癌（LC）患者。采用单因素和多因素分析确定独立预后因素。基于 FAR 和术前肌少症建立新的评分系统（SFAR），并进行统计学分析。
本研究共纳入 198 例符合纳入标准的患者。多因素分析显示，术前肌少症、pTNM 分期和 FAR 是喉癌的独立预后因素。基于这三个指标，我们开发了 SFAR 评分系统。多因素分析显示 SFAR 是喉癌的独立预测因素（p<0.001）。SFAR 随后被纳入包含 T 分期和 N 分期的预后模型，并生成列线图以准确预测其生存情况。
全身炎症和肌少症与喉癌术后预后显著相关。新的评分系统（SFAR）有助于改善接受喉癌手术治疗患者的预后。
