Guo Zijia, Kawamura Kazuhiro
Department of Obstetrics and Gynecology Juntendo University Graduate School of Medicine Tokyo Japan.
Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine Tokyo Japan.
Reprod Med Biol. 2025 Jul 16;24(1):e12666. doi: 10.1002/rmb2.12666. eCollection 2025 Jan-Dec.
With the trend of delayed childbearing, the incidence of poor ovarian response (POR) with diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) has increased. Effective treatments for ovarian function restoration are limited. Platelet-rich plasma (PRP), an autologous regenerative therapy, shows potential for improving ovarian function; however, its mechanisms of action and optimal treatment protocols remain unclear.
A literature review was conducted using PubMed and Google Scholar, covering studies published from January 2021 to March 2025, focusing on preclinical and clinical studies evaluating the effects of PRP on ovarian function.
Preclinical studies indicate that PRP promotes primordial follicle activation and growth. It also enhances oocyte quality by promoting angiogenesis, exerting anti-inflammatory and antioxidative effects, and modulating the extracellular matrix. Clinically, PRP may increase the number of retrieved oocytes and improve certain ovarian reserve markers, but its impact on oocyte quality and pregnancy rates remains inconclusive. The optimal dosage and treatment duration also require further investigation.
PRP holds promise in reproductive medicine, but additional research is required to evaluate long-term effects, optimize treatment protocols, and standardize preparation methods.
随着生育延迟的趋势，卵巢储备功能下降（DOR）和卵巢早衰（POI）导致的卵巢反应不良（POR）发生率有所上升。恢复卵巢功能的有效治疗方法有限。富血小板血浆（PRP）作为一种自体再生疗法，显示出改善卵巢功能的潜力；然而，其作用机制和最佳治疗方案仍不清楚。
使用PubMed和谷歌学术进行文献综述，涵盖2021年1月至2025年3月发表的研究，重点关注评估PRP对卵巢功能影响的临床前和临床研究。
临床前研究表明，PRP可促进原始卵泡的激活和生长。它还通过促进血管生成、发挥抗炎和抗氧化作用以及调节细胞外基质来提高卵母细胞质量。在临床上，PRP可能会增加获卵数并改善某些卵巢储备指标，但其对卵母细胞质量和妊娠率的影响仍无定论。最佳剂量和治疗持续时间也需要进一步研究。
PRP在生殖医学中具有前景，但需要更多研究来评估其长期影响、优化治疗方案并规范制备方法。
