Blake Ryan J, McChesney Grant R, Williams H James, Holland Steven M, Lastinger Allison M
Department of Orthopaedic Surgery, West Virginia University, Morgantown, West Virginia, USA.
Musculoskeletal Infection Program, West Virginia University, Morgantown, West Virginia, USA.
Case Rep Infect Dis. 2025 Jul 9;2025:6970929. doi: 10.1155/crdi/6970929. eCollection 2025.
is a rapidly growing non- (NTM) primarily associated with pulmonary infections, particularly in individuals with underlying lung conditions. While soft tissue infections are less common, their incidence has been increasing. These infections are challenging to treat due to inherent resistance to many antibiotics obtained through spontaneous mutation as well as physical characteristics of the microbes. The case presented here describes a 61-year-old female without obvious risk factors for mycobacterial infection who developed an intramuscular abscess over a 2-year period following a mechanical fall. Surgical resection with a complex antibiotic regimen was required based on macrolide resistance and a lack of established treatment plans for such a rare presentation. This case highlights the increasing incidence of NTM and the variable clinical presentation. Early identification with a combination of surgery and antibiotics is usually indicated to successfully manage these infections. Even without obvious risk factors, NTM infection should be considered in the presence of soft tissue and intramuscular abscesses.
是一种快速增长的非结核分枝杆菌（NTM），主要与肺部感染相关，尤其是在有潜在肺部疾病的个体中。虽然软组织感染不太常见，但其发病率一直在上升。由于通过自发突变获得的对许多抗生素的固有耐药性以及微生物的物理特性，这些感染难以治疗。这里介绍的病例是一名61岁女性，没有明显的分枝杆菌感染危险因素，在一次机械性跌倒后两年内出现了肌内脓肿。基于大环内酯类耐药性以及缺乏针对这种罕见表现的既定治疗方案，需要进行手术切除并采用复杂的抗生素治疗方案。该病例突出了NTM发病率的上升以及临床表现的多样性。通常需要结合手术和抗生素进行早期识别，以成功管理这些感染。即使没有明显的危险因素，在出现软组织和肌内脓肿时也应考虑NTM感染。
