Notation A D, Tagatz G E
Am J Obstet Gynecol. 1977 Aug 1;128(7):747-56. doi: 10.1016/0002-9378(77)90715-3.
Simultaneous determinations of unconjugated estriol and 15alpha-hydroxyestriol (E4) levels in maternal serum were studied serially to ascertain the relative usefulness of these estrogens as indicators of fetal welfare. Complicated pregnancies included 16 patients with pre-eclampsia and/or hypertension, six patients with severe Rh-isoimmunization, 12 patients with diabetes mellitus, of which four had vascular disease, three patients with fetal death in utero, and three twin pregnancies. Retrospective analysis failed to indicate a clinically useful role for serum E4 determinations in the evaluation of fetal welfare during high-risk pregnancies.
连续研究了孕妇血清中未结合雌三醇和15α-羟基雌三醇（E4）水平的同时测定，以确定这些雌激素作为胎儿健康指标的相对效用。复杂妊娠包括16例先兆子痫和/或高血压患者、6例严重Rh血型不合患者、12例糖尿病患者（其中4例有血管疾病）、3例宫内死胎患者和3例双胎妊娠患者。回顾性分析未能表明血清E4测定在高危妊娠胎儿健康评估中的临床有用作用。
