Taylor N F, Shackleton C H
Ann Clin Biochem. 1978 Jan;15(1):1-11. doi: 10.1177/000456327801500101.
Although oestriol measurements are well established for the assessment of 'at risk' pregnancies, there are a number of other oestrogens, excreted during pregnancy, which contain additional hydroxyl groups and might be more sensitive indicators of the condition of mother or fetus. Some of these result from the action of hydroxylases possibly present only in the fetus and others from maternal hydroxylations. We review the evidence for the biosynthesis of these polar oestrogens, summarise methods of measurement, and compare values obtained in normal and pathological pregnancies. There is as yet insufficient evidence to enable their potential value to be confirmed.
尽管雌三醇测定在评估“高危”妊娠方面已得到广泛应用，但孕期还会排泄出许多其他雌激素，它们含有额外的羟基，可能是母亲或胎儿状况更敏感的指标。其中一些是可能仅存在于胎儿体内的羟化酶作用的结果，另一些则来自母体的羟化作用。我们回顾了这些极性雌激素生物合成的证据，总结了测量方法，并比较了正常和病理妊娠中获得的值。目前尚无足够证据证实它们的潜在价值。
