Granger Kyle L, Guillaumin Julien, Williams Kurt, Shropshire Sarah, Ohlendorf Alex, Hall Kelly E
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Department of Biomedical Sciences and Oregon Veterinary Diagnostic Laboratory, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA.
Vet Med Sci. 2025 Jul;11(4):e70472. doi: 10.1002/vms3.70472.
Fibrosing mediastinitis (FM) is a rare but serious condition characterized by excessive fibrous tissue proliferation in the mediastinum, often leading to compression of vital structures. Although considered benign, in people, clinical manifestations of FM can range from asymptomatic incidental findings on imaging studies to severe respiratory compromise and hemodynamic instability. While documented in people, FM has not yet been reported in dogs.
A 5-year-old male neutered Labrador Retriever presented with progressive respiratory distress, leading to pleural effusion and facial swelling. Thoracic radiographs revealed mediastinal mass-like structures and pleural effusion. Computed tomography demonstrated a mediastinal mass-like structure, enlarged tracheobronchial lymph nodes, multifocal narrowing of lobar bronchi and pulmonary veins and compression of the oesophagus and trachea. The dog was humanely euthanized due to poor response to empiric therapy and the owner's perception of suffering. A post-mortem examination confirmed severe chronic mediastinal inflammation with fibrosis and vasculitis consistent with fibrosing mediastinitis.
This report presents a unique case of FM in a dog.
纤维性纵隔炎(FM)是一种罕见但严重的疾病,其特征是纵隔内纤维组织过度增生,常导致重要结构受压。尽管被认为是良性的,但在人类中,FM的临床表现从影像学检查中无症状的偶然发现到严重的呼吸功能不全和血流动力学不稳定不等。虽然在人类中有相关记载,但犬类中尚未报道过FM。
一只5岁已绝育的雄性拉布拉多猎犬出现进行性呼吸窘迫,导致胸腔积液和面部肿胀。胸部X光片显示纵隔有肿块样结构和胸腔积液。计算机断层扫描显示纵隔有肿块样结构、气管支气管淋巴结肿大、叶支气管和肺静脉多处狭窄以及食管和气管受压。由于对经验性治疗反应不佳且主人认为其痛苦,对该犬实施了安乐死。尸检证实存在严重的慢性纵隔炎症,伴有纤维化和血管炎,符合纤维性纵隔炎。
本报告展示了一例犬类FM的独特病例。