Rui H, Haug E, Mevåg B, Thomassen Y, Purvis K
J Reprod Fertil. 1985 Nov;75(2):421-32. doi: 10.1530/jrf.0.0750421.
The effects of a single injection of ovine prolactin on prostatic function were monitored in intact, intact androgenized and castrated-androgenized rats rendered hypoprolactinaemic after 7 days of treatment with a potent dopamine agonist, lisuride. Hypoprolactinaemia was associated with reductions in ventral prostate weight, polyamine levels, lateral lobe zinc and the concentration of the ventral prostate protein prostatein, but an elevation in the level of cytosolic oestradiol binding. Whether these differences attained statistical significance depended on whether the animals were intact, intact-androgenized or castrated-androgenized. With the exception of ventral prostate weight and lateral lobe zinc concentrations, a single injection of prolactin restored or reversed these changes towards control levels within 12 h, which could not be explained by an indirect effect of the hormone on adrenal or testicular function. No effects of lisuride or prolactin were observed with regard to the content of fructose in the coagulating gland or in the degree of prolactin binding to prostatic membranes.
在经强效多巴胺激动剂利舒脲治疗7天后导致低催乳素血症的完整、完整雄激素化和去势雄激素化大鼠中，监测单次注射绵羊催乳素对前列腺功能的影响。低催乳素血症与腹侧前列腺重量、多胺水平、外侧叶锌含量以及腹侧前列腺蛋白前列腺素浓度的降低有关，但与胞质雌二醇结合水平的升高有关。这些差异是否具有统计学意义取决于动物是完整的、完整雄激素化的还是去势雄激素化的。除了腹侧前列腺重量和外侧叶锌浓度外，单次注射催乳素可在12小时内将这些变化恢复或逆转至对照水平，这无法用该激素对肾上腺或睾丸功能的间接作用来解释。未观察到利舒脲或催乳素对凝固腺中果糖含量或催乳素与前列腺膜结合程度有影响。
