Koç İrem, Tellioğlu Hilal Toprak, Babaoğlu Berrin, Söylemezoğlu Figen, Kıratlı Hayyam
Ocular Oncology Service, Department of Ophthalmology, Hacettepe University School of Medicine, 06230, Altındağ, Ankara, Turkey.
Elbistan State Hospital, Kahramanmaraş, Turkey.
Int Ophthalmol. 2025 Jul 18;45(1):296. doi: 10.1007/s10792-025-03675-3.
The aim of this study was to evaluate histopathologically the conjunctival pigmentations occurring in post-enucleation anophthalmic sockets and to identify the common causes.
Retrospective cohort study.
This was a retrospective chart review of patients who presented with conjunctival pigmentation in the anophthalmic socket at a single tertiary care center and who underwent incisional conjunctival biopsy between 2018 and 2022. Demographic and clinicopathological data, and treatment outcomes were retrieved.
A total of 14 consecutive patients aged between 17 and 70 years were enrolled. Indications for primary enucleations were: retinoblastoma in 5 (35.7%), uveal melanoma in 6 (42.8%) patients, ciliary body schwannoma in 1 (7.1%), retinal hemangioblastoma in 1 (7.1%) and endophthalmitis in 1 patient (7.1%). Histopathological diagnoses of conjunctival pigmentations were chronic inflammation in 9 (64.3%), recurrence of melanoma in 2 (14.3%), nevus in 2 (14.3%) patients and in situ squamous cell carcinoma in 1 (7.1%) patient.
Chronic inflammation was the most common cause of secondary conjunctival pigment deposits over the anophthalmic socket following enucleation. Still however, these pigmented spots should be approached judiciously as in overall 35.7% of the cases, and in 33.3% of uveal melanoma patients in particular, malignant or suspicious/precancerous lesions were encountered.
本研究旨在通过组织病理学评估眼球摘除术后无眼球眼眶中出现的结膜色素沉着情况，并确定其常见病因。
回顾性队列研究。
这是一项对在单一三级医疗中心出现无眼球眼眶结膜色素沉着且在2018年至2022年间接受结膜切开活检的患者进行的回顾性病历审查。收集了人口统计学和临床病理数据以及治疗结果。
共纳入14例年龄在17岁至70岁之间的连续患者。初次眼球摘除的指征为：视网膜母细胞瘤5例（35.7%），葡萄膜黑色素瘤6例（42.8%），睫状体神经鞘瘤1例（7.1%），视网膜血管瘤1例（7.1%），眼内炎1例（7.1%）。结膜色素沉着的组织病理学诊断为慢性炎症9例（64.3%），黑色素瘤复发2例（14.3%），痣2例（14.3%），原位鳞状细胞癌1例（7.1%）。
慢性炎症是眼球摘除术后无眼球眼眶继发性结膜色素沉着的最常见原因。然而，仍应谨慎对待这些色素沉着斑，因为总体上35.7%的病例，特别是33.3%的葡萄膜黑色素瘤患者中，遇到了恶性或可疑/癌前病变。
