G0S2作用的最新进展

Recent advances on the role of G0S2.

作者信息

Zhao Xin Hua, Ruan Liqin

机构信息

Department of hepatobiliary surgery Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People's Hospital, Jiujiang, 332000, Jiangxi, China.

出版信息

Discov Oncol. 2025 Jul 18;16(1):1362. doi: 10.1007/s12672-025-03198-4.

DOI:10.1007/s12672-025-03198-4

PMID:40679675

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12274192/

Abstract

G0S2, formally known as G0/G1 switch gene 2, functions as an inhibitor of adipose triglyceride lipase (ATGL), a key enzyme in lipolysis that hydrolyzes triglycerides (TG) to diacylglycerol and fatty acid (FA). G0S2 can directly interact with ATGL, suppressing its hydrolase activity. Recently, G0S2 has been implicated in immune system abnormalities, chronic inflammation, and tumorigenesis. However, the underlying mechanisms and roles of G0S2 in immune system disorders and cancer remain incompletely understood. In this review, we provide an overview of the current knowledge on G0S2, highlighting its regulation at different levels and unveiling its potential as a diagnostic and prognostic marker in immune-related diseases and cancer. The discussion covers the roles of G0S2 in lipolysis, lipid synthesis, inflammation, and various cancers.

摘要

G0S2，正式名称为G0/G1转换基因2，作为脂肪甘油三酯脂肪酶（ATGL）的抑制剂发挥作用，ATGL是脂解过程中的一种关键酶，可将甘油三酯（TG）水解为二酰甘油和脂肪酸（FA）。G0S2可直接与ATGL相互作用，抑制其水解酶活性。最近，G0S2与免疫系统异常、慢性炎症和肿瘤发生有关。然而，G0S2在免疫系统疾病和癌症中的潜在机制和作用仍未完全了解。在本综述中，我们概述了目前关于G0S2的知识，强调其在不同水平的调控，并揭示其作为免疫相关疾病和癌症诊断及预后标志物的潜力。讨论内容涵盖了G0S2在脂解、脂质合成、炎症和各种癌症中的作用。