Martínez-Lucio Tonantzin Samara, Lazarenko Sergiy V, Mendoza-Ibañez Oscar Isaac, Knol Remco J J, Monroy-Gonzalez Andrea G, van der Zant Friso, Tsoumpas Charalampos, Slart Riemer H J A
Department of Nuclear Medicine and Molecular Imaging, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Department of Nuclear Medicine, Northwest Clinics Alkmaar, Alkmaar, The Netherlands.
Int J Cardiovasc Imaging. 2025 Aug;41(8):1605-1617. doi: 10.1007/s10554-025-03468-w. Epub 2025 Jul 18.
Transient ischemic dilation has been conventionally calculated from the static images, and has been scarcely investigated by PET/CT. Therefore, we aim to evaluate the impact of the quantification method and software package on TID ratio by [N]NH PET/CT; moreover, perform a comprehensive evaluation of TID in normal-perfusion and myocardial ischemic patients. Retrospective analysis of 125 [N]NH PET/CT scans with Corridor 4DM and QPS/QGS software packages. TID ratio was calculated from static and gated left ventricular volumes. Comparisons were performed according to ischemic extent and software package. Correlations with LV function and perfusion variables were assessed. TID ratios were significantly higher in ischemic patients (p < 0.05), except for TID gated EDV from QPS/QGS. TID static and TID gated ESV from QPS/QGS were different between the very severe ischemic subgroup and the group without ischemia (p = 0.0003). TID gated ESV from Corridor 4DM was higher in moderate, severe, and very severe ischemic subgroups than the normal-perfusion group (p = 0.02). TID gated ESV presented strong inverse correlations with myocardial flow reserve (MFR) in the very severe ischemic subgroup with Corridor 4DM, and with ejection fraction (LVEF) reserve, independent of the software and percentage of ischemic extent. Upper limits for TID static, ESV, and EDV with QPS/QGS were 1.17, 1.57, and 1.3, respectively. TID static, ESV, and EDV upper limits with Corridor4DM were 1.25, 1.29, and 1.21, respectively. TID ratios from [N]NH PET/CT are higher in ischemic than in normal-perfusion patients and related to ischemic extent. TID ratios correlated strongly with LVEF reserve and MFR. The processing software and metric quantification method may influence the TID ratio.
短暂性缺血性扩张通常是根据静态图像计算得出的，而通过正电子发射断层扫描/计算机断层扫描（PET/CT）对此进行的研究很少。因此，我们旨在通过[N]NH PET/CT评估量化方法和软件包对TID比率的影响；此外，对正常灌注和心肌缺血患者的TID进行全面评估。使用Corridor 4DM和QPS/QGS软件包对125例[N]NH PET/CT扫描进行回顾性分析。根据静态和门控左心室容积计算TID比率。根据缺血程度和软件包进行比较。评估与左心室功能和灌注变量的相关性。缺血患者的TID比率显著更高（p < 0.05），QPS/QGS软件包的门控舒张末期容积（EDV）的TID除外。QPS/QGS软件包的静态TID和门控收缩末期容积（ESV）在极重度缺血亚组和无缺血组之间存在差异（p = 0.0003）。Corridor 4DM软件包的门控ESV在中度、重度和极重度缺血亚组中高于正常灌注组（p = 0.02）。在使用Corridor 4DM软件包的极重度缺血亚组中，门控ESV与心肌血流储备（MFR）呈强负相关，与射血分数（LVEF）储备呈强负相关，且与软件和缺血程度百分比无关。QPS/QGS软件包的静态TID、ESV和EDV的上限分别为1.17、1.57和1.3。Corridor4DM软件包的静态TID、ESV和EDV上限分别为1.25、1.29和1.21。与正常灌注患者相比，缺血患者的[N]NH PET/CT的TID比率更高，且与缺血程度相关。TID比率与LVEF储备和MFR密切相关。处理软件和指标量化方法可能会影响TID比率。
