肾小球基底膜自身抗体放射免疫测定法的临床应用
Clinical application of a radio-immunoassay for auto-antibodies to glomerular basement membrane.
作者信息
Bowman C, Lockwood C M
出版信息
J Clin Lab Immunol. 1985 Aug;17(4):197-202.
PMID:4068032
Abstract
We describe a sensitive radio-immunoassay for auto-antibodies to glomerular basement membrane (GBM). The assay discriminates patients with glomerulonephritis associated with circulating auto-antibodies to glomerular basement membrane from those with other forms of nephritis. Monitoring of antibody levels in sequential serial serum samples enables drug therapy to be tailored precisely to control the aberrant immune response, a situation unique in the management of glomerulonephritis.
摘要
我们描述了一种针对肾小球基底膜（GBM）自身抗体的灵敏放射免疫测定法。该测定法能够区分患有与循环性肾小球基底膜自身抗体相关的肾小球肾炎的患者和患有其他形式肾炎的患者。对连续系列血清样本中的抗体水平进行监测，可使药物治疗精确调整，以控制异常的免疫反应，这在肾小球肾炎的治疗中是一种独特的情况。
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