Pueschel S M, Schrier A M, Povar M L, Boylan J M
J Ment Defic Res. 1985 Sep;29 ( Pt 3):247-56. doi: 10.1111/j.1365-2788.1985.tb00335.x.
Nineteen pregnant Macaca mulatta were fed a special diet throughout the gestational period in an attempt to render them hyperphenylalaninaemic. Group C (control group) received a regular diet, group Lo was given a 'low' phenylalanine diet, group Me a 'median' phenylalanine diet, and group Hi a 'high' phenylalanine diet. Nearly all monkeys had an uncomplicated pregnancy and an uneventful delivery. Biological measurements were obtained shortly after the birth of the infants and behavioural assessments were done when the offspring were between 6 and 18 months of age. The results of the biological and behavioural evaluations revealed that there was no statistically significant difference among the respective study groups. We concluded that a combination of factors inherent in an imperfect animal model may account for the negative results of this study.
19只怀孕的恒河猴在整个妊娠期被喂食特殊饮食，试图使它们出现高苯丙氨酸血症。C组（对照组）接受常规饮食，Lo组给予“低”苯丙氨酸饮食，Me组给予“中”苯丙氨酸饮食，Hi组给予“高”苯丙氨酸饮食。几乎所有猴子的孕期都很顺利，分娩也很正常。在婴儿出生后不久进行了生物学测量，并在后代6至18个月大时进行了行为评估。生物学和行为评估的结果显示，各研究组之间没有统计学上的显著差异。我们得出结论，不完善的动物模型中固有的多种因素可能是本研究结果为阴性的原因。
