DePass L R, Maronpot R R, Weil C S
J Toxicol Environ Health. 1985;16(1):55-60. doi: 10.1080/15287398509530718.
Several important components of photocurable coatings were studied for dermal tumorigenic activity by repeated application to the skin of mice. The substances tested were 2-ethylhexyl acrylate (EHA) and methylcarbamoyloxyethyl acrylate (MCEA) (monomers); neopentyl glycol diacrylate (NPGDA), esterdiol-204-diacrylate (EDDA), and pentaerythritol tri(tetra)acrylate (PETA) (cross-linkers); and three acrylated urethane oligomers. For each bioassay, 40 C3H/HeJ male mice were dosed 3 times weekly on the dorsal skin for their lifetime with the highest dose of the test agent that caused no local irritation or reduction in body weight gain. Two negative control groups received acetone (diluent) only. A positive control group received 0.2% methylcholanthrene (MC). NPGDA and EHA had significant tumorigenic activity with tumor yields of eight and six tumor-bearing mice (three and two malignancies), respectively. The MC group had 34 mice with carcinomas and 1 additional mouse with a papilloma. MCEA had no dermal tumorigenic activity but resulted in early mortality. No skin tumors in the treatment area were observed in the other groups. Additional studies will be necessary to elucidate possible relationships between structure and tumorigenic activity for the acrylates.
通过反复涂抹于小鼠皮肤，研究了光固化涂料的几种重要成分的皮肤致瘤活性。所测试的物质有丙烯酸2-乙基己酯（EHA）和丙烯酸甲氨基甲酰氧基乙酯（MCEA）（单体）；新戊二醇二丙烯酸酯（NPGDA）、酯二醇-204-二丙烯酸酯（EDDA）和季戊四醇三（四）丙烯酸酯（PETA）（交联剂）；以及三种丙烯酸化聚氨酯低聚物。对于每项生物测定，40只C3H/HeJ雄性小鼠在其一生中每周3次在背部皮肤涂抹不会引起局部刺激或体重增加减少的最高剂量测试剂。两个阴性对照组仅接受丙酮（稀释剂）。一个阳性对照组接受0.2%的甲基胆蒽（MC）。NPGDA和EHA具有显著的致瘤活性，肿瘤发生率分别为8只和6只荷瘤小鼠（3只和2只恶性肿瘤）。MC组有34只小鼠患癌，另有1只小鼠患乳头状瘤。MCEA没有皮肤致瘤活性，但导致早期死亡。其他组在治疗区域未观察到皮肤肿瘤。需要进一步研究以阐明丙烯酸酯的结构与致瘤活性之间的可能关系。
