Linh Duong Thuy, Shabbir Muhammad Nadir
Faculty of Management Sciences, National Economics University, Hanoi, Vietnam.
School of Economics and Finance, Xi'an university of Finance and Economics, China; School of Economics, Renmin University of China, China.
J Virol Methods. 2025 Dec;338:115223. doi: 10.1016/j.jviromet.2025.115223. Epub 2025 Jul 16.
Monkeypox, a zoonotic illness caused by the Monkeypox virus (MPXV), is a re-emerging disease that has resurfaced as a prominent global public health issue in the 21st century. The 2022 outbreak, previously limited to Central and West Africa, exhibited extraordinary global dissemination, prompting critical inquiries over the virus's transmission mechanisms and containment strategies. This paper analyzes monkeypox's pathophysiology, epidemiological trends, and public health ramifications, emphasizing diagnostic difficulties, underreporting, and the inequitable access to vaccines and therapies. The discussion encompasses the significance of genomic surveillance, One Health strategies, and the necessity for research on effective antivirals and vaccines. Substantial knowledge deficiencies, encompassing virus mutation hazards and a restricted comprehension of animal reservoirs, impede preventative initiatives. Mitigating future epidemics necessitates addressing these problems through improved diagnoses, equitable vaccination distribution, and enhanced surveillance. This paper examines the present status of Monkeypox research and delineates prospective directions to inform global public health policies.
猴痘是一种由猴痘病毒（MPXV）引起的人畜共患疾病，是一种再度出现的疾病，在21世纪已再度成为一个突出的全球公共卫生问题。2022年的疫情此前局限于中非和西非，但却出现了异常的全球传播，引发了对该病毒传播机制和控制策略的关键质疑。本文分析了猴痘的病理生理学、流行病学趋势及公共卫生影响，强调了诊断困难、报告不足以及疫苗和治疗方法获取的不平等。讨论内容包括基因组监测的重要性、“同一健康”策略以及研发有效抗病毒药物和疫苗的必要性。包括病毒突变风险和对动物宿主了解有限在内的大量知识空白阻碍了预防措施。减轻未来的疫情需要通过改进诊断、公平分配疫苗和加强监测来解决这些问题。本文审视了猴痘研究的现状，并描绘了未来方向，以为全球公共卫生政策提供参考。
