Farman Muhammad, Nisar Kottakkaran Sooppy, Sambas Aceng, Bayram Mustafa, Hafez Mohamed
Department of Mathematics, Faculty of Art and Sciences, Near East University, Nicosia, Turkey.
Faculty of Informatics and Computing, Universiti Sultan Zainal Abidin, Campus Besut, 22200, Kuala Terengganu, Terengganu, Malaysia.
Sci Rep. 2025 Jul 19;15(1):26202. doi: 10.1038/s41598-025-07412-9.
Alzheimer's disease, a prevalent neurological condition causing dementia, is characterized by hyperphosphorylated tau protein intracellular neurofibrillary tangles and amyloid beta-peptide extracellular plaques. Currently, medication cannot cure, stop, or slow its progression. This paper presents a novel epidemiological model for Alzheimer's disease, considering both integer and fractional order operators to characterize the temporal dynamics of key cell populations. The analysis reveals a single solution to a proposed system with a positively invariant region. The Banach fixed-point theorem and Krasnoselskii type are used to investigate the uniqueness of the model. Local and global stability characteristics are analyzed, and the disease impact on compartments and community-wide transmission rates is evaluated. The study conducts a sensitivity analysis of parameters using chaos analysis. A linear feedback control strategy is employed to manage chaotic situations by directing system dynamics towards equilibrium points. A numerical scheme utilizing the Newton polynomial interpolation method is presented in the study, along with its solutions and MATLAB simulations that demonstrate the behavior of the model. With different results for varying values, the fractal fractional order model performs better in medical interventions than the conventional integer order model, pointing to new possibilities for advancement. The study improves our understanding of the progression and recurrence of neurological diseases, which will benefit in disease spread investigation and the development of control techniques.
阿尔茨海默病是一种导致痴呆的常见神经疾病,其特征是细胞内神经原纤维缠结的tau蛋白过度磷酸化以及细胞外淀粉样β肽斑块。目前,药物无法治愈、阻止或减缓其进展。本文提出了一种针对阿尔茨海默病的新型流行病学模型,考虑整数阶和分数阶算子来表征关键细胞群体的时间动态。分析揭示了一个具有正不变区域的所提出系统的单一解。运用巴拿赫不动点定理和克拉索夫斯基型定理来研究模型的唯一性。分析了局部和全局稳定性特征,并评估了疾病对各部分以及全社区传播率的影响。该研究使用混沌分析对参数进行敏感性分析。采用线性反馈控制策略,通过将系统动态导向平衡点来管理混沌情况。研究中提出了一种利用牛顿多项式插值方法的数值格式,以及其解和MATLAB模拟,展示了模型的行为。对于不同的值有不同的结果,分形分数阶模型在医学干预方面比传统整数阶模型表现更好,指出了新的发展可能性。该研究增进了我们对神经疾病进展和复发的理解,这将有利于疾病传播调查和控制技术的发展。