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[已撤回] Toll样受体4的抑制作用可保护大鼠胰岛免受脂多糖诱导的功能障碍。

[Retracted] Inhibition of TLR4 protects rat islets against lipopolysaccharide‑induced dysfunction.

作者信息

Wang Xiao, Ge Qin Min, Bian Fan, Dong Yan, Huang Chun Mei

机构信息

Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China.

Department of Nephrology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China.

出版信息

Mol Med Rep. 2025 Oct;32(4). doi: 10.3892/mmr.2025.13622. Epub 2025 Jul 19.

Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the lower two flow cytometric plots shown in Fig. 3A on p. 809 (namely, the plots for the 'anti‑TLR4+LPS' and 'TLR4‑shRNA+LPS' experiments), these appeared to show similar groupings of dots, which would not have been anticipated if these experiments had been performed discretely under different experimental conditions, suggesting a fundamental flaw either in the way in which these experiments were performed, or in how the results were outputted. The Editor of has decided that this paper should be retracted from the Journal on account of a lack of confidence in the presented data. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 15: 805‑812, 2017; DOI: 10.3892/mmr.2016.6097].

摘要

上述论文发表后,一位细心的读者提请编辑注意,关于第809页图3A中所示的下方两张流式细胞仪图(即“抗TLR4 + LPS”和“TLR4-shRNA + LPS”实验的图),这些图似乎显示出相似的点群,如果这些实验是在不同实验条件下分别进行的,这是不会预期到的,这表明这些实验的进行方式或结果输出方式存在根本缺陷。《分子医学报告》的编辑决定,鉴于对所呈现数据缺乏信心,应从该期刊撤回这篇论文。已要求作者对这些问题作出解释,但编辑部未收到答复。编辑就由此造成的不便向读者致歉。[《分子医学报告》15: 805 - 812, 2017; DOI: 10.3892/mmr.2016.6097]

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