Yamada S, Takezawa J, Takagi H, Abe T, Sakurai S, Kobayashi S
Jpn J Med. 1985 Aug;24(3):223-30. doi: 10.2169/internalmedicine1962.24.223.
Histologic features of 112 liver biopsy specimens from patients with alcoholic liver injury were studied. Alcoholic hyalin was found in 6 specimens (5.4%). Spherical giant mitochondria were detected in 9 specimens (8.0%). Fatty metamorphosis, infiltration by polymorphonuclear leucocytes, and pericellular fibrosis were observed in many specimens. Zonal or submassive necrosis was also found in 20 specimens (17.9%). Cholestasis was seen in 32 specimens (28.6%). Histologic changes in interlobular bile ducts were investigated in 103 specimens containing such ducts. Among 31 specimens with cholestasis, changes in interlobular bile ducts were detected in 19 specimens (61.3%), whereas biopsy specimens without cholestasis showed the changes in only 4 of 72 (5.6%). Changes observed in interlobular bile ducts included inflammatory cell infiltration and vacuolation of epithelium in most specimens. Swollen or flattened epithelial cells, karyopyknosis and eosinophilic degeneration were observed in many. These results suggest that the changes of interlobular bile ducts may be partially related to cholestasis in alcoholic liver injury.
对112例酒精性肝损伤患者的肝活检标本的组织学特征进行了研究。在6份标本（5.4%）中发现了酒精性透明小体。在9份标本（8.0%）中检测到球形巨大线粒体。许多标本中观察到脂肪变性、多形核白细胞浸润和细胞周围纤维化。20份标本（17.9%）中还发现了带状或亚大块坏死。32份标本（28.6%）中出现胆汁淤积。在103份含有小叶间胆管的标本中研究了小叶间胆管的组织学变化。在31份有胆汁淤积的标本中，19份（61.3%）检测到小叶间胆管变化，而无胆汁淤积的活检标本在72份中仅有4份（5.6%）出现变化。在小叶间胆管观察到的变化包括大多数标本中的炎性细胞浸润和上皮细胞空泡化。许多标本中观察到上皮细胞肿胀或扁平、核固缩和嗜酸性变性。这些结果表明，小叶间胆管的变化可能与酒精性肝损伤中的胆汁淤积部分相关。
