解读17-β-羟基类固醇脱氢酶4：从分子洞察到癌症治疗

Deciphering 17-β-hydroxysteroid dehydrogenase 4: from molecular insights to cancer therapeutics.

作者信息

Liao Meng-Bin, Lau Andy T Y, Xu Yan-Ming

机构信息

The First Affiliated Hospital of Shantou University Medical College, Shantou, 515041, Guangdong, People's Republic of China.

Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, 515041, Guangdong, People's Republic of China.

出版信息

Cancer Cell Int. 2025 Jul 19;25(1):273. doi: 10.1186/s12935-025-03885-w.

DOI:10.1186/s12935-025-03885-w

PMID:40684154

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12276699/

Abstract

17-β-hydroxysteroid dehydrogenase 4 (HSD17B4), abundantly present in the peroxisomal regions of mammalian cells, is an oxidoreductase that catalyzes the oxidoreduction of steroid substrates. Impairment of lipid metabolism represents one of the most critical metabolic alterations in cancer, with lipid metabolic processes tightly linked to tumor cell proliferation, survival, invasion, and metastasis. HSD17B4 is primarily involved in the regulation of cellular fatty acid and hormone metabolism. Therefore, HSD17B4 is closely related to tumors, but few relevant studies exist. Polymorphisms and methylation of the HSD17B4 gene, as well as acetylation of the HSD17B4 protein, influence its expression and function, impacting cancer progression and therapeutic response. Recent findings also highlight HSD17B4 as a potential therapeutic target and prognostic biomarker in various cancers. Here, we will discuss the latest literature on human HSD17B4 and its clinical implications.

摘要

17-β-羟基类固醇脱氢酶4（HSD17B4）大量存在于哺乳动物细胞的过氧化物酶体区域，是一种催化类固醇底物氧化还原反应的氧化还原酶。脂质代谢受损是癌症中最关键的代谢改变之一，脂质代谢过程与肿瘤细胞的增殖、存活、侵袭和转移密切相关。HSD17B4主要参与细胞脂肪酸和激素代谢的调节。因此，HSD17B4与肿瘤密切相关，但相关研究较少。HSD17B4基因的多态性和甲基化，以及HSD17B4蛋白的乙酰化，会影响其表达和功能，进而影响癌症进展和治疗反应。最近的研究结果还突出了HSD17B4作为各种癌症潜在治疗靶点和预后生物标志物的作用。在此，我们将讨论关于人类HSD17B4的最新文献及其临床意义。