• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Targeting sex steroid biosynthesis for breast and prostate cancer therapy.

作者信息

Poutanen Matti, Hagberg Thulin Malin, Härkönen Pirkko

机构信息

Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland.

Turku Center for Disease Modelling, University of Turku, Turku, Finland.

出版信息

Nat Rev Cancer. 2023 Sep 8. doi: 10.1038/s41568-023-00609-y.

DOI:10.1038/s41568-023-00609-y
PMID:37684402
Abstract
摘要

相似文献

1
Targeting sex steroid biosynthesis for breast and prostate cancer therapy.针对性类固醇生物合成进行乳腺癌和前列腺癌治疗。
Nat Rev Cancer. 2023 Sep 8. doi: 10.1038/s41568-023-00609-y.
2
Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer.性类固醇诱导的细胞凋亡作为治疗抗激素耐药性乳腺癌和前列腺癌的合理策略。
Discov Med. 2016 May;21(117):411-27.
3
A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers.雄激素诱导前列腺癌和乳腺癌细胞凋亡的统一生物学。
Endocr Relat Cancer. 2018 Feb;25(2):R83-R113. doi: 10.1530/ERC-17-0416. Epub 2017 Nov 21.
4
Adrenal Steroids and Resistance to Hormonal Blockade of Prostate and Breast Cancer.肾上腺皮质类固醇与前列腺癌和乳腺癌对激素阻断的抵抗。
Endocrinology. 2023 Jan 9;164(3). doi: 10.1210/endocr/bqac218.
5
Steroid Hormone Biosynthesis Metabolism Is Associated With Fatigue Related to Androgen Deprivation Therapy for Prostate Cancer.类固醇激素生物合成代谢与前列腺癌雄激素剥夺治疗相关的疲劳有关。
Front Cell Dev Biol. 2021 May 17;9:642307. doi: 10.3389/fcell.2021.642307. eCollection 2021.
6
Sex-steroid hormones and EGF signalling in breast and prostate cancer cells: targeting the association of Src with steroid receptors.乳腺癌和前列腺癌细胞中的性甾体激素与表皮生长因子信号传导：靶向Src与甾体受体的关联
Steroids. 2008 Oct;73(9-10):880-4. doi: 10.1016/j.steroids.2008.01.023. Epub 2008 Feb 8.
7
Cholesterol biogenesis is a PTEN-dependent actionable node for the treatment of endocrine therapy-refractory cancers.胆固醇生物合成是内分泌治疗耐药性癌症的一个依赖于 PTEN 的可操作节点。
Cancer Sci. 2023 Nov;114(11):4365-4375. doi: 10.1111/cas.15960. Epub 2023 Sep 14.
8
First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis.首创小分子抑制剂抑制 CYP11A1 和类固醇激素生物合成。
Mol Cancer Ther. 2022 Dec 2;21(12):1765-1776. doi: 10.1158/1535-7163.MCT-22-0115.
9
Targeting rapid action of sex steroid receptors in breast and prostate cancers.针对乳腺癌和前列腺癌中快速作用的性激素受体。
Front Biosci (Landmark Ed). 2011 Jun 1;16(6):2224-32. doi: 10.2741/3849.
10
The epidemiology of sex steroid hormones and their signaling and metabolic pathways in the etiology of prostate cancer.性类固醇激素及其信号传导和代谢途径在前列腺癌病因学中的流行病学
J Steroid Biochem Mol Biol. 2004 Nov;92(4):237-53. doi: 10.1016/j.jsbmb.2004.10.002. Epub 2005 Jan 5.

引用本文的文献

1
Deciphering 17-β-hydroxysteroid dehydrogenase 4: from molecular insights to cancer therapeutics.解读17-β-羟基类固醇脱氢酶4：从分子洞察到癌症治疗
Cancer Cell Int. 2025 Jul 19;25(1):273. doi: 10.1186/s12935-025-03885-w.
2
Targeting Prostate Cancer Metabolism Through Transcriptional and Epigenetic Modulation: A Multi-Target Approach to Therapeutic Innovation.通过转录和表观遗传调控靶向前列腺癌代谢：治疗创新的多靶点方法
Int J Mol Sci. 2025 Jun 23;26(13):6013. doi: 10.3390/ijms26136013.
3
Steroid hormones and influence of therapeutic drugs in Chinese postmenopausal rheumatoid arthritis patients.

本文引用的文献

1
Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities.不同种族人群中成年人类肠道微生物群的性别和年龄相关轨迹具有共享性。
Nat Aging. 2021 Jan;1(1):87-100. doi: 10.1038/s43587-020-00014-2. Epub 2021 Jan 14.
2
Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation.癌症相关成纤维细胞分泌的氨基葡萄糖通过上调 HSD3B1 改变前列腺癌中的雄激素生物合成程序。
J Clin Invest. 2023 Apr 3;133(7):e161913. doi: 10.1172/JCI161913.
3
Prospective role of 3βHSD1 in prostate cancer precision medicine.
甾体激素及治疗药物对中国绝经后类风湿关节炎患者的影响。
Front Immunol. 2025 May 12;16:1589798. doi: 10.3389/fimmu.2025.1589798. eCollection 2025.
4
Steroid hormone levels vary with sex, aging, lifestyle, and genetics.类固醇激素水平随性别、年龄、生活方式和基因而变化。
Sci Adv. 2025 Mar 28;11(13):eadu6094. doi: 10.1126/sciadv.adu6094.
5
Novel biomarkers and drug correlations of non-canonical WNT signaling in prostate and breast cancer.前列腺癌和乳腺癌中非经典WNT信号通路的新型生物标志物与药物相关性
Discov Oncol. 2024 Sep 30;15(1):511. doi: 10.1007/s12672-024-01394-2.
6
Targeting the cancer cells and cancer-associated fibroblasts with next-generation FGFR inhibitors in prostate cancer co-culture models.在前列腺癌共培养模型中，使用下一代 FGFR 抑制剂靶向癌细胞和癌相关成纤维细胞。
Cancer Med. 2024 Sep;13(18):e70240. doi: 10.1002/cam4.70240.
7
Trends in research on nanomedicine in urologic cancer: a bibliometric and visualized analysis.泌尿外科癌症纳米医学研究趋势：文献计量与可视化分析
Discov Oncol. 2024 Aug 23;15(1):366. doi: 10.1007/s12672-024-01249-w.
8
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets.肿瘤起始与早期癌变：分子机制与干预靶点。
Signal Transduct Target Ther. 2024 Jun 19;9(1):149. doi: 10.1038/s41392-024-01848-7.
9
Enzalutamide Sensitizes Castration-Resistant Prostate Cancer to Copper-Mediated Cell Death.恩杂鲁胺使去势抵抗性前列腺癌对铜介导的细胞死亡敏感。
Adv Sci (Weinh). 2024 Aug;11(30):e2401396. doi: 10.1002/advs.202401396. Epub 2024 Jun 10.
3βHSD1在前列腺癌精准医学中的前瞻性作用。
Prostate. 2023 May;83(7):619-627. doi: 10.1002/pros.24504. Epub 2023 Feb 26.
4
A commentary on the origins of 11-ketotestosterone.关于11-酮睾酮起源的一篇评论。
Eur J Endocrinol. 2022 Oct 26;187(6):C5-C8. doi: 10.1530/EJE-22-0820. Print 2022 Dec 1.
5
First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis.首创小分子抑制剂抑制 CYP11A1 和类固醇激素生物合成。
Mol Cancer Ther. 2022 Dec 2;21(12):1765-1776. doi: 10.1158/1535-7163.MCT-22-0115.
6
Association of HSD3B1 Genotype and Clinical Outcomes in Postmenopausal Estrogen-Receptor-Positive Breast Cancer.绝经后雌激素受体阳性乳腺癌中HSD3B1基因分型与临床结局的关联
Ann Surg Oncol. 2022 Oct;29(11):7194-7201. doi: 10.1245/s10434-022-12088-w. Epub 2022 Jul 1.
7
Basics of androgen synthesis and action.雄激素的合成和作用基础。
Best Pract Res Clin Endocrinol Metab. 2022 Jul;36(4):101665. doi: 10.1016/j.beem.2022.101665. Epub 2022 May 6.
8
Management of prostate cancer by targeting 3βHSD1 after enzalutamide and abiraterone treatment.在恩杂鲁胺和阿比特龙治疗后通过靶向 3βHSD1 来管理前列腺癌。
Cell Rep Med. 2022 May 17;3(5):100608. doi: 10.1016/j.xcrm.2022.100608. Epub 2022 Apr 20.
9
Intracrine androgen biosynthesis and drug resistance.内分泌雄激素生物合成与耐药性。
Cancer Drug Resist. 2020 Nov 3;3(4):912-929. doi: 10.20517/cdr.2020.60. eCollection 2020.
10
Conversion of Classical and 11-Oxygenated Androgens by Insulin-Induced AKR1C3 in a Model of Human PCOS Adipocytes.胰岛素诱导的 AKR1C3 在多囊卵巢综合征脂肪细胞模型中对经典和 11-氧代雄激素的转化。
Endocrinology. 2022 Jul 1;163(7). doi: 10.1210/endocr/bqac068.