Peng Luting, Yan Wu, Shi Yanan, Cao Mengyao, Liu Qianqi, Li Xiaonan
Department of Children Health Care, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Clinical Medical Research Center, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Ann Med. 2025 Dec;57(1):2531249. doi: 10.1080/07853890.2025.2531249. Epub 2025 Jul 20.
Reference interval for serum uric acid (SUA) in children is based on adult standards. This study aimed to determine the reference interval and influencing factors of SUA in healthy children and adolescents.
From August 2020 to August 2022, 7,742 healthy children and adolescents aged 3-15 years receiving physical examinations at the Children's Health Care Department at Children's Hospital of Nanjing Medical University were recruited. A reference interval of SUA among children and adolescents was determined and validated in a cohort of 2,968 children. Influencing factors of SUA levels were identified by linear regression analyses.
Among 7,742 healthy children and adolescents with an average age of 8.2 ± 2.3 years, the average SUA level was 4.5 ± 0.98 mg/dl, and significantly higher in boys than girls. Age-specific increase in the SUA level started from the age of 8 years. A significantly higher SUA level was detected in boys than in girls among those older than 12 years. The reference interval of SUA among healthy children and adolescents in the age groups of 3-8 years, 9-10 years, 11 years was established as 2.8-6.1 mg/dl, 2.9-6.4 mg/dl, and 3.1-7.4 mg/dl, respectively. For those aged 12-15 years, the reference interval of SUA was 3.5-8.7 mg/dl in boys and 3.4-7.7 mg/dl in girls. Linear regression analysis indicated that SUA was positively correlated with the body fat percentage, skeletal muscle mass, and alanine aminotransferase, while negatively correlated with estimated glomerular filtration rate.
The distributions of SUA levels are age and gender-specific among healthy children and adolescents in Nanjing, China. The established distinct reference interval of SUA and diagnostic criteria for hyperuricemia in this population may assist in the clinical management of related diseases.
儿童血清尿酸（SUA）的参考区间是基于成人标准确定的。本研究旨在确定健康儿童和青少年SUA的参考区间及影响因素。
2020年8月至2022年8月，招募了7742名在南京医科大学附属儿童医院儿童保健科接受体检的3至15岁健康儿童和青少年。在2968名儿童队列中确定并验证了儿童和青少年SUA的参考区间。通过线性回归分析确定SUA水平的影响因素。
在7742名平均年龄为8.2±2.3岁的健康儿童和青少年中，SUA平均水平为4.5±0.98mg/dl，男孩显著高于女孩。SUA水平从8岁开始随年龄增长而升高。12岁以上儿童中，男孩的SUA水平显著高于女孩。3至8岁、9至10岁、11岁健康儿童和青少年的SUA参考区间分别确定为2.8至6.1mg/dl、2.9至6.4mg/dl和3.1至7.4mg/dl。12至15岁儿童中，男孩的SUA参考区间为3.5至8.7mg/dl，女孩为3.4至7.7mg/dl。线性回归分析表明，SUA与体脂百分比、骨骼肌质量和丙氨酸氨基转移酶呈正相关，与估计肾小球滤过率呈负相关。
在中国南京，健康儿童和青少年的SUA水平分布具有年龄和性别特异性。本研究建立的该人群SUA不同参考区间和高尿酸血症诊断标准可能有助于相关疾病的临床管理。
