Rota Muriel, Morales-Suárez-Varela María, Donzelli Gabriele
Department of Pharmacy, University of Pisa, 56126 Pisa (PI), Italy.
Research Group in Social and Nutritional Epidemiology, Pharmacoepidemiology and Public Health, Department of Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine, Faculty of Pharmacy and Food Sciences, Universitat de València, 46100 Burjassot (Valencia), Spain; Biomedical Research Center in Epidemiology and Public Health Network (CIBERESP), Carlos III Health Institute, 28029 Madrid (Madrid), Spain.
Nutrition. 2025 Nov;139:112878. doi: 10.1016/j.nut.2025.112878. Epub 2025 Jun 16.
The aim of this pilot study was to assess the impact of the Mediterranean diet (MD) on anthropometric measures, including BMI, fat-free mass, fat mass, and total body water, in overweight pediatric patients.
This nutritional intervention was carried out on 33 pediatric patients (aged between 7 and 17 years (mean age = 11.88 years) with excess weight. Anthropometric measurements, a lipid profile, a glucose profile, and abdominal ultrasound data were collected during the initial visit. At the follow-up visit, anthropometric and body composition data were collected again. Adherence to the MD was assessed using the KIDMED questionnaire. The study was conducted from February 2024 to July 2024.
At the start, hepatic steatosis was present in 90% of patients, 30% had abnormal cholesterol and triglyceride levels, 10% had normal HDL cholesterol, 20% were insulin-resistant, and 82% of the children were likely to become obese adults based on age- and sex-specific BMI cut-offs proposed by Cole et al., which extrapolate childhood BMI percentiles to predict adult obesity risk. After treatment, BMI decreased, primarily due to an increase in height and either a reduction or maintenance of weight. There was a small reduction in fat-free mass, but this change was minimal. In contrast, a more significant decrease in fat mass and increase in total body water were observed.
These results suggest that dietary treatment led to body recomposition. The results confirm the global concern regarding pediatric obesity. The MD led to favorable changes in body composition, but further studies with larger samples and control groups are needed to assess the long-term effectiveness of dietary treatment.
本试点研究旨在评估地中海饮食(MD)对超重儿科患者人体测量指标的影响,包括体重指数(BMI)、去脂体重、脂肪量和总体水含量。
对33名超重儿科患者(年龄在7至17岁之间,平均年龄 = 11.88岁)进行了这项营养干预。在初次就诊时收集了人体测量数据、血脂谱、血糖谱和腹部超声数据。在随访就诊时,再次收集了人体测量和身体成分数据。使用KIDMED问卷评估对MD的依从性。该研究于2024年2月至2024年7月进行。
开始时,90%的患者存在肝脂肪变性,30%的患者胆固醇和甘油三酯水平异常,10%的患者高密度脂蛋白胆固醇正常,20%的患者有胰岛素抵抗,根据Cole等人提出的按年龄和性别划分的BMI临界值,82%的儿童有可能成为肥胖成年人,该临界值外推儿童BMI百分位数以预测成人肥胖风险。治疗后,BMI下降,主要是由于身高增加以及体重减轻或维持不变。去脂体重略有减少,但这种变化很小。相比之下,观察到脂肪量有更显著的减少,总体水含量增加。
这些结果表明饮食治疗导致了身体成分的重新组合。结果证实了对儿科肥胖的全球关注。MD导致了身体成分的有利变化,但需要更大样本和对照组的进一步研究来评估饮食治疗的长期有效性。