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[高血压患者中HLA抗原的分布]

[Distribution of HLA antigens in patients with hypertension].

作者信息

Rudnev V I, Pospelov L E, Osipov S G, Suvorov Iu I, Malenko A F

出版信息

Kardiologiia. 1985 Aug;25(8):38-40.

PMID:4068458
Abstract

An immunogenetic study of 71 patients with essential hypertension associated with no signs of heart or renal failure, and 276 normal Russian male residents of Moscow demonstrated a significantly increased frequency of antigens HLA-B13 (p less than 0.01) and HLA-B22 (p less than 0.05), as well as HLA-A11 (p less than 0.05), in the hypertensive sample. Aggravated heredity (familial hypertension) was established in 64% of hypertensive carriers of antigens HLA-B13 and HLA-B22.

摘要

对71例无心脏或肾衰竭迹象的原发性高血压患者以及276名莫斯科正常俄罗斯男性居民进行的免疫遗传学研究表明,高血压样本中抗原HLA - B13(p<0.01)、HLA - B22(p<0.05)以及HLA - A11(p<0.05)的频率显著增加。在HLA - B13和HLA - B22抗原的高血压携带者中,64%被确定存在遗传加重情况(家族性高血压)。

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