Shkhvatsabaya I K, Osipov S G, Rudnev V I, Titov V N
Cor Vasa. 1984;26(6):408-14.
Heredity factors are of great importance in the pathogenesis of essential hypertension, but their role was until recently not reliably proved. It was only after research into histocompatibility antigens that it was possible to discover the genetic determination of a number of diseases. The purpose of the study was to reveal the genetic factors raising the risk of essential hypertension (EH). In the population of Russian nationality in Moscow, suffering from EH, HLA antigens and certain complement components were investigated. The results showed an increased frequency of HLA-A11, HLA-B13 and HLA-Bw22. However, blood C3c and C4 concentration was in the studied group of patients significantly elevated, which attests to a possible participation of the complement system in the development of EH as a factor causing vasoconstriction. The results confirm the need for further study of the immunogenetic profile of patients with EH in order to clarify certain aspects of the pathogenesis of EH.
遗传因素在原发性高血压的发病机制中具有重要意义，但直到最近其作用仍未得到可靠证实。只有在对组织相容性抗原进行研究之后，才有可能发现许多疾病的遗传决定因素。本研究的目的是揭示增加原发性高血压（EH）风险的遗传因素。在莫斯科的俄罗斯族人群中，对患有EH的患者进行了HLA抗原和某些补体成分的调查。结果显示HLA-A11、HLA-B13和HLA-Bw22的频率增加。然而，在研究的患者组中，血液C3c和C4浓度显著升高，这证明补体系统可能作为导致血管收缩的因素参与EH的发生发展。结果证实有必要进一步研究EH患者的免疫遗传特征，以阐明EH发病机制的某些方面。
