[脑啡肽对大鼠实验性心肌梗死代谢指标的影响]
[Effect of enkephalins on metabolic indices in experimental myocardial infarct in rats].
作者信息
Zoloev G K, Slepushkin V D, Titov M I
出版信息
Kardiologiia. 1985 Aug;25(8):72-4.
PMID:4068468
Abstract
An experimental study in rats demonstrated that myocardial infarction, induced by the ligation of the descending branch of the left coronary artery, led to marked metabolic disorders, such as increased lactate and glucose levels and decreased levels of blood calcium and magnesium and hepatic glycogen. A stable analogue of leu-enkephalin administered to the animals normalized metabolic parameters and improved the course of experimental myocardial infarction in rats.
摘要
一项在大鼠身上进行的实验研究表明，通过结扎左冠状动脉降支诱导的心肌梗死会导致明显的代谢紊乱，如乳酸和葡萄糖水平升高，血钙、血镁和肝糖原水平降低。给动物注射亮脑啡肽的稳定类似物可使代谢参数正常化，并改善大鼠实验性心肌梗死的病程。
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