[亮氨酸脑啡肽类似物达乐argin对实验性心肌梗死中交感-肾上腺系统成分的影响]
[Effect of the leucine enkephalin analog dalargin on the components of the sympathetico-adrenal system in experimental myocardial infarction].
作者信息
Afonskaia N I, Anikin A Iu, Kargina-Terent'eva R A
出版信息
Kardiologiia. 1990 Feb;30(2):78-81.
A histofluorescence study was made of catecholamine saturation of the adrenergic nervous plexuses of the intact zone of rabbit left ventricles and adrenal medullas on days 3 and 7 of experimental myocardial infarction induced by ligation of the anterior branch of the left coronary artery when dalargrin, a leucine-enkephalin analogue, was administered. Dalargin was shown to decrease catecholamine saturation of myocardial nervous plexuses and to reduce detection rates of mediator accumulation in the sympathetic axons of nervous fascicles. In addition, the agent caused a decrease in the hormone content in chromaffinocytes on day 3 of the experiment and contributed to recovery of their functional homogeneity.
对结扎左冠状动脉前支诱导实验性心肌梗死第3天和第7天的家兔左心室完整区和肾上腺髓质的肾上腺素能神经丛进行了儿茶酚胺饱和度的组织荧光研究，实验过程中给予亮氨酸脑啡肽类似物达拉根。结果显示，达拉根可降低心肌神经丛的儿茶酚胺饱和度，并降低神经束交感轴突中介质积累的检出率。此外，该药物在实验第3天可使嗜铬细胞中的激素含量降低，并有助于其功能同质性的恢复。
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