脊髓脊膜膨出管理研究及其他：脊髓脊膜膨出管理的趋势与创新

The Management of Myelomeningocele Study and Beyond: Trends and Innovations in the Management of Myelomeningocele.

作者信息

Fogel Hart, Adapa Arjun R, Teasley Damian E, Feldstein Neil A

机构信息

Department of Neurosurgery, Columbia University Irving Medical Center, New York, New York, USA.

出版信息

World Neurosurg. 2025 Jul;199:123983. doi: 10.1016/j.wneu.2025.123983.

DOI:10.1016/j.wneu.2025.123983

PMID:40685172

Abstract

Myelomeningocele is the most common congenital abnormality of the central nervous system and carries significant morbidity. The results of the landmark Management of Myelomeningocele Study, published in 2011, established prenatal surgical repair of the neural tube defect as a viable treatment option. This paper provides an overview of innovations in the treatment of myelomeningocele that have emerged since the Management of Myelomeningocele Study, including the refinement of less-invasive fetoscopic techniques for prenatal myelomeningocele repair and the development of various stem cell therapies.

摘要

脊髓脊膜膨出是中枢神经系统最常见的先天性异常，具有显著的发病率。2011年发表的具有里程碑意义的脊髓脊膜膨出管理研究结果，确立了神经管缺陷的产前手术修复作为一种可行的治疗选择。本文概述了自脊髓脊膜膨出管理研究以来出现的脊髓脊膜膨出治疗方面的创新，包括用于产前脊髓脊膜膨出修复的微创胎儿镜技术的改进以及各种干细胞疗法的发展。